| 引用本文： |
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陈会松,何承志,王胜兰,等.肝硬化门静脉高压性肺动脉高压 临床特点及免疫学分析[J].同济大学学报（医学版）,2014,35(1):69-72. [点击复制]
- CHEN Hui-song,HE Cheng-zhi,WANG Sheng-lan,et al.Clinical characteristics and immunological changes of cirrhosis patients with portopulmonary hypertension[J].同济大学学报（医学版）,2014,35(1):69-72. [点击复制]
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| 摘要: |
| 目的探讨肝硬化门静脉高压性牌动脉高压（portopulmonary hypertension, POPH)的临床特点及免疫学改变。方法将100例肝硬化患者分为POPH组及非POPH组，比较两组患者的临床特点。测定POPH患者T细 胞亚群及NKCD16+CD56细胞的表达水平。结果100例肝硬化并门静脉高压患者中10例合并POPH。POPH大小与Child-Pugh分级无关（P>0.05)。两组患者丙肝肝硬化患病率差异有统计学意义（P<0.05)。两组间患者合并（portal vein thrombosis, PVT)的比例差异有统计学意义（50% vs 16.7% ,P<0.05)。8例病毒性肝硬化并 POPH患者中，有6例患者NKCD16+CD56细胞数目降低。结论门脉高压肝硬化患者可伴发POPH。HCV感染、PVT以及NKCD16+CD56降低在POPH形成过程中可能起重要作用。 |
| 关键词: 肝硬化 门静脉高压 门静脉高压性肺动脉高压 |
| DOI：10.3969/j.issnl008-0392.2014.01.014 |
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| 基金项目:国家自然科学基金(81070343) |
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| Clinical characteristics and immunological changes of cirrhosis patients with portopulmonary hypertension |
| CHEN Hui-song1,HE Cheng-zhi2,WANG Sheng-lan2,YANG Chang-qing2 |
| (1. Dept. of Gastroenterology, Third People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 201999, China;2. Dept. of Grastroenterology, Tongji Hospital, Tongji University, Shanghai 200065, China) |
| Abstract: |
| Objective To review the clinical characteristics and immunological changes of patients with portopulmonary hypertension (POPH).Methods One hundred patients with liver cirrhosis were divided into POPH and the non-POPH groups. The clinical characteristics were compared between two groups, and T cell and NKCD16+56 cell levels in peripheral blood samples were measured in POPH patients. Results There were 10 patients with POPH in 100 cirrhosis patients. POPH was not correlated with Child-Pugh classes (P>0.05).However, there were significant differences in prevalence of HCV cirrhosis and portal vein thrombosis (PVT) between two groups (P<0.05). NKCD16 +56 cells were decreased in 6 of 8 viral liver cirrhosis patients with POPH. Conclusion Patients with portal hypertension liver cirrhosis may complicated by POPH，and HCV infection，PVT，decreased NKCD16+56 cells may be associated with POPH. |
| Key words: cirrhosis portal hypertension portopulmonary hypertension |
