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张韬,陈明,马静,等.速度向量技术测定糖尿病患者肱动脉血管的生物力学性质[J].同济大学学报（医学版）,2013,34(4):64-67. [点击复制]
- ZHANG Tao,CHEN Ming,MA Jing,et al.Biomechanical properties of brachial artery measured by velocity vector imaging in patients with type 2 diabetes[J].同济大学学报（医学版）,2013,34(4):64-67. [点击复制]
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| 速度向量技术测定糖尿病患者肱动脉血管的生物力学性质 |
| 张韬,陈明,马静,张宇辉,刘盛林,冯波 |
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| (上海市浦东新区惠南镇社区卫生服务中心,上海201301;同济大学附属东方医院心脏医学部,上海200120;同济大学附属东方医院内分泌科,上海200120) |
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| 摘要: |
| 目的采用速度向量技术（velocity vector imaging，VVI）评价2型糖尿病患者肱动脉的生物力学特征。方法2型糖尿病患者和健康对照组各20例，于基础状态和舌下含服硝酸甘油（nitroglycerin，NTG）后，分别应用二维超声与VVI技术测定肱动脉舒张末期内径、面积与血管应变。通过Langewouters公式计算肱动脉血管力学参数，并描绘糖尿病组和对照组在两种状态下肱动脉的压力一血管面积曲线与应变一应力曲线。结果糖尿病组NTG状态下肱动脉血管内径增量、血管面积增量、血管壁应力的降幅均较对照组明显减小（P〈0．05），应变一应力曲线出现右移现象。结论VVI可评判在体肱动脉的生物力学特征，并为无创性判定糖尿病患者外周血管病变生物力学分析提供了新思路。 |
| 关键词: 2型糖尿病 肱动脉 生物力学 超声检查 速度向量技术 |
| DOI：10.3969/j. issnl008 -0392.2013.04.015 |
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| 基金项目:上海市浦东新区卫生系统学科带头人基金（PW2010A-38）;上海市浦东新区科技发展基金创新资金（PKJ2010一Y16）;上海市浦东新区心血管疾病学科群项目（PWZxkq2010-01） |
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| Biomechanical properties of brachial artery measured by velocity vector imaging in patients with type 2 diabetes |
| ZHANG Tao,CHEN Ming,MA Jing,ZHANG Yu-hui,LIU Sheng-lin,FENG Bo |
| (Township Community Health Service Center, Pudong New District, Shanghai 201301, China;Heart Center, East Hospital, Tongji University, Shanghai 200120, China;Dept. of Endocrinology, East Hospital, Tongji University, Shanghai 200120, China) |
| Abstract: |
| Objective To evaluate the application of two-dimensional ultrasonography and vetoclty vector imaging （VVI） in measurement of biomechanical properties of brachial artery （BA） in patients with type 2 diabetes mellitus （T2DM）. Methods Twenty patients with T2DM were enrolled in the study and 20 healthy subjects served as controls. Ultrasound images of BA were displayed and diameter, area and strian of BA were documented from the sonogram and VVI. Biomechanical data in BA were calculated according to Langewouters＇ equation. Curves of pressure-area and stress-strain were mapped and compared at baseline and during nitroglycerin intervention in the patients and the controls. Results Increments of diameter, area, compliance and the decrements of stress of BA were attenuated after intervention of nitroglycerine significantly （P 〈 0. 05 ）. Strain-stress curve was markedly shifted rightward in T2DM patients compared to that of controls. Conclusion VVI can effectively assess the biomechanical properties of BA, which provides a non-invasive measure for analysis of peripheral artery in patients with T2DM. |
| Key words: type 2 diabetes brachial artery biomechanics ultrasonography velocity vector imaging |