| 引用本文： |
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李红梅,唐兆生,冯波.诺和锐30短期治疗对初发2型糖尿病患者胰岛β细胞功能的影响[J].同济大学学报（医学版）,2013,34(4):61-63. [点击复制]
- LI Hong-mei,TANG Zhao-sheng,FENG Bo.Effects of short-term Aspart 30 treatment on pancreatic β-cell function in patients with newly-diagnosed type 2 diabetes[J].同济大学学报（医学版）,2013,34(4):61-63. [点击复制]
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| 摘要: |
| 目的探讨诺和锐30短期治疗对初发2型糖尿病患者胰岛β细胞功能和血糖控制的影响。方法采用自身对照的方法，对49例新诊断未治疗的2型糖尿病患者给予3个月的诺和锐30治疗，分析比较治疗前后血糖、胰岛素、C肽和胰岛素分泌功能各指标的变化。结果治疗后，空腹血糖、2h血糖、糖化血红蛋白均明显下降，胰岛素分泌指数、胰岛素敏感指数均明显升高。胰岛素抵抗指数明显下降。结论诺和锐30治疗3个月可显著改善初发2型糖尿病患者的β细胞分泌功能和胰岛素敏感性，减轻胰岛素抵抗，改善糖代谢。 |
| 关键词: 2型糖尿病 诺和锐30 胰岛β细胞功能 |
| DOI：10.3969/j. issnl008 -0392.2013.04.014 |
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| 基金项目: |
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| Effects of short-term Aspart 30 treatment on pancreatic β-cell function in patients with newly-diagnosed type 2 diabetes |
| LI Hong-mei,TANG Zhao-sheng,FENG Bo |
| (Dept. of Endocrinology, East Hospital, Tongji University, Shanghai 200120, China) |
| Abstract: |
| Objective To investigate the effects of short-term Aspart 30 treatment on pancreatic β- cell function and blood glucose control in patients with newly-diagnosed type 2 diabetes. Methods Forty nine patients with newly-diagnosed type 2 diabetes received Aspart 30 for three months. Levels in blood glucose, insulin, C-peptide were measured before and after treatmen. Results After treatment, fasting glucose, 2 h glucose and HbA1C were decreased significantly, insulin secretion index and insulin sensitivity index were significantly increased. Insulin resistance index decreased significantly. Conclusion Aspart 30 can significantly improve the β-cell secretory function, insulin sensitivity and glucose control in patients with newly-diagnosed type 2 diabetes. |
| Key words: type 2 diabetes Aspart 30 islet β-cell function |
