| 引用本文： |
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陆紫敏,王秀芹,祖亚钧,等.自身免疫性溶血性贫血患者部分免疫活性细胞表达的研究[J].同济大学学报（医学版）,2011,32(6):63-66. [点击复制]
- LU Zi-Min,WANG Xiu-Qin,ZU Ya-jun,et al.Cellular immunity in patients with autoimmune hemolytic anemia[J].同济大学学报（医学版）,2011,32(6):63-66. [点击复制]
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| 摘要: |
| 目的 探讨部分免疫活性细胞与自身免疫性溶血性贫血（autoimmune hemolytic anemia,AIHA）发病的关系及输血影响。方法 将67例AIHA患者作为观察组,其中28例输血患者为A组,70例非AIHA其他贫血患者作为对照组,其中30例输血患者为B组。采用流式细胞术测定观察组部分免疫细胞活性水平,并分别与对照组、正常健康组测定值比较,同时对A、B两组患者进行输血前后部分免疫指标比较。结果 ①观察组用药前外周血CD3＋、CD4＋、CD4＋/CD8＋、NK细胞活性水平均显著低于正常组（P＜0.05）;观察组CD19~＋指标上升明显高于对照组,而对照组CD19＋指标又明显高于正常组,（P＜0.05）均有统计学意义。②联合检测AIHA患者T细胞亚群、B细胞、NK细胞的阳性表达率高于单项阳性表达率。③A组输血后外周血CD3＋、CD4＋、CD4＋/CD8＋比值上升、CD19＋细胞表达下降较治疗前有明显差异。结论 AIHA患者存在外周血部分免疫活性细胞表达异常,输血能改善AIHA患者的细胞免疫平衡调节功能。 |
| 关键词: 免疫性溶血性贫血 免疫细胞 活性 输血 |
| DOI：10.3969/j.issn1008-0392.2011.06.013 |
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| 基金项目:上海市卫生局科研项目(WSJ1102) |
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| Cellular immunity in patients with autoimmune hemolytic anemia |
| LU Zi-Min,WANG Xiu-Qin,ZU Ya-jun,LIANG Ping,ZHEN Wei-Ping |
| (Dept.of Blood Transfusion,Tongji Hospital,Tongji University,Shanghai 200065,China) |
| Abstract: |
| Objective To investigate the cellular immunity autoimmune hemolytic anemia(AIHA) and the effect of transfusion.Methods Sixty seven AIHA patients,including 28 receiving blood transfusion (group A) and 70 non-AIHA patients,including 30 receiving transfusion(group B) were enrolled in the study.The levels of CD3＋,CD4＋,CD4＋/CD8＋,CD19＋ were determined by flow cytometry(PCM). Those immune indicators were compared between ALHA and non-AIHA patients;before and after transfusion.Results The levels of the peripheral blood of T cell subgroup and NK cell activities in AIHA patients were significantly lower than those of non-AIHA group(P＜0.05).The abnormal rate of combined tests of T cell subgroup,B cells and NK cells in AIHA patients was higher than that of single tests. The expression of CD3＋,CD4＋,and CD4＋CD8＋ in group A increased and CD19＋ declined after transfusion. Conclusion Blood transfusion can improve the abnormal cell immunity function in AMA patients. |
| Key words: autoimmune hemolytic anemia immunocyte active transfusion |
