| 摘要: |
| DNA甲基化是最常见的表观遗传修饰之一，在基因表达、基因组稳定性和肿瘤的发生发展上具有重要的作用。DNA甲基化标志物检测具有简单、经济和组织特异性的特征，可用于肿瘤早期诊断、预后评估和疗效监测等，具有很高的临床应用价值。本文就DNA甲基化特征、作用机制、检测方法以及在女性生殖系统肿瘤等的临床应用最新进展进行评述，以提高DNA甲基化检测在妇科肿瘤精准诊断中的水平。 |
| 关键词: DNA甲基化 肿瘤标志物 诊断 |
| DOI：10.12289/j.issn.1008-0392.22202 |
| 投稿时间：2022-05-14 |
| 基金项目:国家自然科学基金(82170082)；上海市科学技术委员会医学重点科技攻关专项基金(09411951600)；上海市自然科学基金(19ZR1448500)；上海市科学技术委员会医学引导类项目基金(19411964700)；同济大学附属同济医院临床研究培育重点项目（ITJ(ZD)2105） |
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| DNA methylation detection assists accurate diagnosis of gynecological tumors |
| JIANG Minghua,YI Xianghua |
| (Department of Obstetrics and Gynecology, Shanghai Minhang District Central Hospital, Fudan University, Shanghai 201100, China;Department of Pathology, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China) |
| Abstract: |
| DNA methylation is one of the most common epigenetic modifications involved in gene expression, genome stability and tumor development. Detection of DNA methylation markers have the advantages of simple method, less cost and strong tissue specificity. The clinical application of DNA methylation detection includes early diagnosis, prognosis evaluation, efficacy monitoring and so on. This commentary reviews the characteristics, mechanism, detection methods of DNA methylation, and the latest progress of clinical application in female reproductive system tumors, which may assist accurate diagnosis of gynecological tumors. |
| Key words: DNA methylation tumor markers diagnosis |
