| 引用本文： |
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姚安洁,饶晗钰,王冰冰,等.急性肺损伤鼠类模型的研究进展[J].同济大学学报（医学版）,2022,43(5):749-756. [点击复制]
- YAO Anjie,RAO Hanyu,WANG Bingbing,et al.Advances in murine models of acute lung injury[J].同济大学学报（医学版）,2022,43(5):749-756. [点击复制]
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| 摘要: |
| 急性呼吸窘迫综合征是导致急性呼吸衰竭的重要原因，已经成为重症监护病房患者发生率和死亡率最高的疾病之一，其根本原因是目前急性呼吸窘迫综合征的发病机制复杂多样且尚未明确。因此，建立合适的急性肺损伤鼠类模型有助于研究急性呼吸窘迫综合征的发病机制、治疗方案及预防策略。本文就实验动物选择、急性肺损伤模型建立方法及其应用进展进行综述。 |
| 关键词: 急性呼吸窘迫综合征 急性肺损伤 鼠类模型 免疫缺陷 |
| DOI：10.12289/j.issn.1008-0392.22130 |
| 投稿时间：2022-04-03 |
| 基金项目:国家自然科学基金（82272673） |
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| Advances in murine models of acute lung injury |
| YAO Anjie,RAO Hanyu,WANG Bingbing,WANG Changhui,XIE Shuanshuan |
| (Department of Respiratory Medicine， Shanghai Tenth People’s Hospital， Tongji University School of Medicine， Shanghai 200072;School of Medicine， Tongji University， Shanghai 200092， China) |
| Abstract: |
| Acute respiratory distress syndrome(ARDS) is a common condition with the high morbidity and mortality among patients in the intensive care unit, the pathogenetic mechanisms of ARDS are complex and diverse which are not fully understood. Appropriate animal models of acute lung injury(ALI) can help researchers to get a closer look of the pathogenetic mechanism and find better treatment and prevention solutions for ARDS. This review aims to introduce how to choose appropriate animals for modeling, how to establish an ALI murine model, and how to apply these models in scientific research on ARDS. |
| Key words: acute respiratory distress syndrome acute lung injury murine models immune deficiency |
