| 摘要: |
| 可降解材料是指在实现力学性能后“全身而退”的材料，是骨科、心脑血管科等学科理想的植入物选择。可降解镁基材料是其中具有代表性的一种，具有化学和机械性能良好、有效抑制平滑肌细胞增生、促进血管内皮化、降解所导致的炎症反应轻微等优势。但镁基血管内支架也有着降解过快等问题，目前主要通过加强纯镁纯度、优化合金成分、加用涂层等方式改善镁基材料性能，从而减缓降解速率。本文将对可降解镁基血管支架对外周血管的影响的研究进展进行综述。 |
| 关键词: 可降解 镁 材料 血管支架 外周血管 |
| DOI：10.12289/j.issn.1008-0392.21442 |
| 投稿时间：2021-10-17 |
| 基金项目:上海市浦东新区临床高峰学科（急危重症PWYgf2021-03)；上海市公共卫生重点学科—灾难医学与卫生应急管理（GWV-10.1-XK21） |
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| Advances in research on effects of degradable magnesium-based vascular stent on peripheral vassels |
| WU Fan,WANG Tao |
| (Department of Orthopedics and Traumatology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200123, China) |
| Abstract: |
| As a choice for ideal graft, biodegradable material can be degraded completely after realizing mechanical performance. The biodegradable magnesium-based material is such an ideal material and now is close to clinical application due to its advantages of having good chemical and mechanical performance, inhibiting the proliferation of smooth muscle cells, promoting vascular endothelial growth, and mild inflammatory response. The rapid degradation is still a problem for clinical application, however, the degradation rate of the material can be slowed down by increasing the purity of magnesium, optimizing the alloy composition, and adding the coating lay. In this article, the research progress on the effects of biodegradable magnesium-based vascular stent on peripheral vassels is reviewed. |
| Key words: biodegradable magnesium material vascular stent peripheral vascular |
