| 引用本文： |
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王天景,黄润之,贾景一,等.基于SEER数据库的不同年龄组恶性周围神经鞘膜瘤预后的研究[J].同济大学学报（医学版）,2021,42(3):381-387. [点击复制]
- WANG Tian-jing,HUANG Run-zhi,JIA Jing-yi,et al.Prognosis of malignant peripheral nerve sheath tumor in different age groups： a SEER population-based study[J].同济大学学报（医学版）,2021,42(3):381-387. [点击复制]
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| 摘要: |
| 目的基于美国国立癌症研究所“监测、流行病学和结果”(the Surveillance, Epidemiology and End Results, SEER)数据库
探讨不同年龄层次恶性周围神经鞘瘤（malignant peripheral nerve sheath tumor， MPNST）患者的
预后。方法从SEER数据
库中选择1973—2014年被诊断为MPNST的患者。使用Kaplan-Meier法和COX比例风险模型分析年龄与预后的关系。并在不同亚组中分析不同年龄段死亡风险的差异。结果COX分析结果显示，与≥60岁年龄组相比，<20岁组HR=0.47（95%CI： 0.33~0.66）、20~39岁组HR=0.61（95%CI： 0.49~0.77）、40~50岁组HR=0.55（95%CI： 0.44~0.70）。在肿瘤分期为“局部”和“区域”的患者中，年龄是患者预后的独立预测因素（P<0.01），分期为“远处转移”的患者不同年龄组间死亡风险的差异无统计学意义（P＞0.05）。在不同原发部位中，年龄均是患者预后的独立预测因素（P<0.01）。结论年龄是MPNST患者独立的预后预测因素。≥60岁年龄组的患者死亡风险显著高于其他年龄组。 |
| 关键词: 恶性周围神经鞘瘤 预后分析 亚组分析 SEER数据库 |
| DOI：10.12289/j.issn.1008-0392.20287 |
| 投稿时间：2020-06-24 |
| 基金项目:浙江省医药卫生科技计划项目（2016KYA034） |
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| Prognosis of malignant peripheral nerve sheath tumor in different age groups： a SEER population-based study |
| WANG Tian-jing,HUANG Run-zhi,JIA Jing-yi,LI Zhen-yu,ZHANG Jian-ying,ZHANG Jie |
| (School of Medicine, Tongji University, Shanghai 200092, China;Clinical Laboratory, Cancer Hospital of the University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou 310022, China) |
| Abstract: |
| ObjectiveTo investigate the prognosis of malignant peripheral nerve sheath tumor（MPNST) in different age groups based on the Surveillance, Epidemiology, and End Results（SEER) database. MethodsA total of 689 patients diagnosed with MPNST from 1973 to 2014 were collected from SEER database. Kaplan-Meier method and COX proportional hazards model were used to analyze the relationship between age and prognosis; and the mortality risk at different age groups was also analyzed. ResultsCOX analysis showed that compared with the age group≥60 years, the HR=0.47（95%CI： 0.33-0.66) in the<20 years old, the HR=0.61（95%CI： 0.49-0.77) in the 20-39 years group, and the HR=0.55（95%CI： 0.44-0.70) in the 40-50 years group. In patients with local and regional tumor, age was an independent predictor of prognosis（P<0.01); while there was no significant difference in death risk among different age groups of patients with distant metastasis（P>0.05). Age was an independent predictor of prognosis in different primary sites（P<0.01). ConclusionAge is an independent predictor of prognosis in patients with MPNST, and the mortality risk of patients aged ≥60 years is higher than that in other age groups. |
| Key words: malignant peripheral nerve sheath tumor prognostic analysis subgroup analysis SEER database |
