| 摘要: |
| 目的 探讨血清胱抑素C（cystatin C, Cyc C）与脑白质病变（white matter lesions, WML）发生的相关性，寻找影响WML发生的危险因素。方法 收集WML病例（86例）与非WML病例（54例），分别收集患者年龄、糖尿病史、高血压史、饮酒史等临床指标，以及Cyc C、肌酐（creatinine, CREA）、肾小球滤过率（glomerular filtration rate, GFR）、三酰甘油（triglyceride, TG）、总胆固醇（total cholesterol, TC）、低密度脂蛋白胆固醇（low density lipoprotein cholesterol, LDL-C）等生化指标，同时行头颅核磁共振成像（magnetic resonance imaging, MRI）检查；采用Logistic回归方法分析WML发生相关危险因素。结果 WML患者与非WML患者间进行比较，年龄、Cyc C、CREA、GFR、TC、糖尿病史、高血压史、饮酒史等差异有统计学意义(P＜0.05)；而两组间性别构成比、吸烟史、TG、LDL-C和颈IMT的数值差异无统计学意义(P＞0.05)。其中年龄、饮酒史、高血压史、糖尿病史、TC、Cyc C和GFR与WML的发生存在相关性(P＜0.05)，Cyc C是WML发生的危险因素之一。在WML患者中，病变范围和程度不同，Cyc C异常率间的差异有统计学意义（P值均＜0.05）。结论 Cyc C与WML的发生存在相关性；通过监测血清Cyc C指标，将有助于预测WML的患病风险。 |
| 关键词: 脑小血管病 脑白质病变 血清胱抑素C 肾功能 |
| DOI：10.16118/j.1008-0392.2019.02.019 |
| 投稿时间：2018-11-03 |
| 基金项目:国家自然科学基金面上项目（81571033） |
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| Study on the correlation between Cystatin C and white matter lesions |
| LU Li-bo,ZHAO Yan-xin |
| (School of Medicine, Tongji University, Shanghai 200092, China;Dept. of Neurology, Tenth People’s Hospital, Tongji University, Shanghai 200072, China) |
| Abstract: |
| Objective The study was aimed to investigate the correlation between serum cystatin C (Cyc C) and the occurrence of white matter lesions(WML), and to explore the risk factors affecting the occurrence of WML.
Methods Participants with WML and non-WMLwere enrolled in this study. Clinical parameters and blood biochemical indications (including Cyc C and so on) were collected, and head magnetic resonance imaging (MRI) was performed for each participant. The multivariate logistic regression analysis was used to analyze the suspected riskfactors.
Results By comparing the WMLgroup with non-WML group, we found that age, Cyc C level, CREA, GFR, TC, history of diabetes, and history of drinking in two groups were statistically significant (P＜0.05). However, the gender ratios, history of smoking, TG, LDL-C and IMT in two groups were not statistically significant (P＞0.05). And a correlation between age, Cyc C level, history of drinking, history of diabetes, TC, GFR and WML occurrence was observed (P＜0.05), Cyc C was one of the risk factor for WML. In addition, a significant difference of Cyc C level according to the range and extent of disese was observed in WML (P＜0.05). Conclusion There is a correlation between Cyc C and WML. The level of plasma Cyc C can be used as an indicator to help estimate the risk of WML. |
| Key words: cerebral small vessel disease white matter lesions cystatin C renal function |
