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  • 肖 虎,冯 景,糜 军,等.肺癌患者血清同型半胱氨酸水平的变化[J].同济大学学报(医学版),2019,40(2):240-243.    [点击复制]
  • XIAO Hu,FENG Jing,MEI Jun,et al.Serum homocysteine levels in patients with lung cancer[J].同济大学学报(医学版),2019,40(2):240-243.   [点击复制]
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肺癌患者血清同型半胱氨酸水平的变化
肖虎,冯景,糜军,侯照远,杜颖
0
(上海交通大学医学院基础医学院,上海 200025; 上海交通大学附属第六人民医院南院检验科,上海 201499)
摘要:
目的 探讨血清同型半胱氨酸(homocysteine, Hcy)水平在肺癌诊断及分期中的临床意义。方法 收集2016年1月—2018年5月期间未经任何治疗的95例初发肺癌患者住院期间的血清Hcy的检测结果。同时收集62例健康体检者及62例肺部感染者空腹血清,采用酶循环法检测血清Hcy水平。所有肺癌患者均明确病理分型。所得数据使用GraphPad Prism 6.0进行分析。结果 肺癌组的血清Hcy水平显著高于健康对照组,差异有统计学意义(P<0.0001),其中肺癌组中TNM分期Ⅳ期的肺癌患者血清Hcy水平显著高于TNM分期Ⅰ~Ⅲ期肺癌患者(P<0.0001)。肺部感染组的血清Hcy水平显著高于健康对照组,差异有统计学意义(P<0.05),肺癌组和肺部感染组之间的血清Hcy水平无差异(P>0.05)。结论 肺癌患者血清Hcy水平增高,晚期肺癌患者Hcy水平高于早、中期患者。血清Hcy水平对肺癌具有一定的诊断价值,但对于肺部感染患者与肺癌的鉴别诊断无价值。
关键词:  肺癌  同型半胱氨酸  肺癌分期  诊断
DOI:10.16118/j.1008-0392.2019.02.020
投稿时间:2018-11-09
基金项目:国家自然科学基金面上项目(31671415)
Serum homocysteine levels in patients with lung cancer
XIAO Hu,FENG Jing,MEI Jun,HOU Zhao-yuan,DU Ying
(Shanghai Jiao Tong University College of Basic Medical Sciences, Shanghai 200025, China; Dept. of Clinical Laboratory, Sixth People’s Hospital South Campus, Shanghai Jiao Tong University, Shanghai 201499, China)
Abstract:
Objective To investigate the clinical significance of serum homocysteine (Hcy) level in patients with lung cancer. Methods Fasting blood samples were collected from 95 lung cancer patients, 62 healthy subjects and 62 lung infection patients. Serum Hcy levels were detected by enzyme circulation method. The data were analyzed with GraphPad Prism 6.0. Results The serum Hcy levels of lung cancer patients were significantly higher than those of healthy controls (P<0.000 1), and the serum Hcy levels in patients with TNM stage Ⅳ stage lung cancer were significantly higher than those of stage Ⅰ-Ⅲ lung cancer patients (P<0.000 1). The serum Hcy level of lung infection group was significantly higher than that of healthy control group (P<0.05). There was no significant difference in serum Hcy levels between the lung cancer patients and the lung infection patients (P>0.05). Conclusion The serum Hcy levels are increased in lung cancer patients and in lung infection patients. The Hcy levels in late stage lung cancer patients are higher than those in early or middle stage patients.
Key words:  lung cancer  homocysteine  lung cancer stage  diagnosis

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