| 引用本文： |
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申晓娜,姚 岚,沙 巍.结核病宿主导向治疗研究进展[J].同济大学学报（医学版）,2019,40(1):123-127. [点击复制]
- SHEN Xiao-na,YAO Lan,SHA Wei.Research progress on host-directed therapy for tuberculosis[J].同济大学学报（医学版）,2019,40(1):123-127. [点击复制]
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| 摘要: |
| 宿主导向治疗（host-directed therapy, HDT）是一种新的有效的结核病的辅助治疗方法。它针对宿主靶蛋白，通过调节宿主对结核分枝杆菌（mycobacterium tuberculosis, MTB）各种免疫通路，达到最大限度杀死细菌和减少炎症所致组织损伤的目的，用于辅助传统的化学治疗或可缩短治疗疗程、减少细菌耐药的产生，此方法为结核病耐药问题凸显、治疗措施有限的情况提供了新的选择。选择适当的宿主导向治疗是至关重要的，本文探讨了一系列的宿主途径和药物，一些已经批准用于临床使用，可能为结核病提供新的辅助治疗方法。 |
| 关键词: 宿主导向治疗 结核病 辅助治疗 免疫通路 药物 |
| DOI：10.16118/j.1008-0392.2019.01.023 |
| 投稿时间：2018-08-05 |
| 基金项目:上海市申康三年行动计划重大疾病临床技能提升项目（16CR1028B） |
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| Research progress on host-directed therapy for tuberculosis |
| SHEN Xiao-na,YAO Lan,SHA Wei |
| (Clinical Research Center of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University, Shanghai 200433, China; Shanghai Key Laboratory of Tuberculosis, Shanghai 200433, China) |
| Abstract: |
| Host-directed therapy(HDT) is a new and promising approach for treatment of tuberculosis. Acting on host target proteins，HDT modulates specific immune pathways to achieve maximum bacterial killing effects and minimum inflammatory tissue damage. Combined with conventional chemical therapy HDT may shorten the treatment course and avoid the development of bacterial resistance to antibiotic agents. This article reviews a range of host pathways and related drugs, some of which have been clinically used to provide new adjunctive therapies for tuberculosis. |
| Key words: host directed therapy tuberculosis adjuvant therapy immune pathways drugs |
