| 引用本文： |
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秦珊珊,余飞.碳酸锂应用于131I治疗Graves病的研究进展[J].同济大学学报（医学版）,2018,39(2):127-132. [点击复制]
- QIN Shan-shan,YU Fei.Research progress on application of lithium carbonate in radioiodine treatment of Graves’disease[J].同济大学学报（医学版）,2018,39(2):127-132. [点击复制]
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| 摘要: |
| 国内外研究证实，短时程、低剂量的碳酸锂辅以131I治疗Graves病可以明显提高131I对Graves病的治愈率。但因对碳酸锂应何时开始服用、服用剂量、治疗效果以及是否存在不良反应等方面尚存争议，故长期以来就131I治疗Graves病常规辅以碳酸锂的治疗未获一致意见。本文综述了碳酸锂在Graves病131I治疗中的应用，包括联合应用碳酸锂时131I使用剂量的调整、碳酸锂的联用对GD患者血清甲状腺激素水平、甲状腺体积、甲状腺功能亢进眼病、甲减发生情况、治愈情况及其安全性。以期能更为清晰地认识碳酸锂在131I治疗Graves病中的应用价值，使Graves病的放射性碘治疗更趋完善。 |
| 关键词: 放射性核素碘 碳酸锂 Graves病 辅助疗法 |
| DOI：10.16118/j.1008-0392.2018.02.025 |
| 投稿时间：2017-05-16 |
| 基金项目:国家自然科学基金项目（81301993） |
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| Research progress on application of lithium carbonate in radioiodine treatment of Graves’disease |
| QIN Shan-shan,YU Fei |
| (Dept. of Nuclear Medicine, Tenth People’s Hospital, Tongji University, Shanghai 200072, China) |
| Abstract: |
| A short-term, low-dose addition of lithium carbonate to 131I have been demonstrated effective in enhancing the cure rate of Graves’disease. However, there has been no consensus in the timing, dosage, efficacy and adverse effects of lithium therapy. This article summarizes the application of lithium carbonate in the radioiodine treatment of Graves’disease, including the adjustment of 131I dose, impact on thyroid hormones and thyroid volume, the safety of therapy, the thyroid-associated ophthalmopathy and hypothyroidism. Hope the information would be useful for the application of lithium therapy to improve radioiodine treatment of Graves’disease. |
| Key words: radioactive iodine lithium carbonate Graves’disease adjuvant treatment |
