| 摘要: |
| Neuroplastin（np)是属于免疫球蛋白超家族、富含于突触膜的细胞黏附分子，有np65和np55两种异构体。np65是脑特异性的，np55是全身分布的。Neuroplastin可在长时程增强、突触可塑性和促进神经突起生长等方面发挥作用，可能与学习、记忆、情感有关。本文对Neuroplastin的结构、分布和功能进行综述。 |
| 关键词: Neuroplastin 细胞黏附 神经突起生长 突触可塑性 情感 |
| DOI：10.16118/j.1008-0392.2017.05.023 |
| 投稿时间：2016-11-18 |
| 基金项目:国家自然科学基金（81371213、81070987、30971531）；上海市大学生创新项目（1500107066） |
|
| Research progress in neuroplastin as cell adhesion molecule |
| QIAO Meng,YUAN Qiong-lan |
| (Dept. of Anatomy and Neurobiology, School of Medicine, Tongji University， Shanghai 200092, China) |
| Abstract: |
| Neuroplastin(np) belonging to the immunoglobulin(Ig) superfamily, is a synapse-enriched adhesion molecule. There are two isomers of neuroplastin, named np65 and np55 according to their molecular weight； np65 is brain-specific, while np55 is widely distributed in various tissues. Neuroplastinsins played a role in long-term potential, synaptic plasticity and promoting neurite outgrowth，which may be associated with learning, memory and mood. In this review, the molecular structure, distribution and biological functions of neuroplastins are focused. |
| Key words: Neuroplastin cell adhesion neurite growth synaptic plasticity mood |
