FANG Qi,QIAN Qiao-hui,GUO Jian,et al.Prevalence of thyroid nodules and its intervention in patients with metabolic syndrome[J].同济大学学报（医学版）,2017,38(2):89-94. [点击复制]
(Dept.of Endocrinology, Zhoupu Hospital, Pudong New Area, Shanghai 201318, China;Medical Examination Center, Zhoupu Hospital, Pudong New Aera, Shanghai 201318, China)
Abstract:
Objective To assess the prevalence of thyroid nodules and its intervention in patients with metabolic syndrome. Methods A total of 1 000 patients diagnosed with metabolic syndrome in the Medical Examination Center of Zhoupu Hospital were recruited in this study. On-site survey and follow-up study were conducted among those patients. The general condition, living habits, and family history of thyroid disease were documented; the height, weight, waist circumference, hip circumference, and blood pressure were measured; the blood glucose testing, blood lipids, liver function, renal function and thyroid function indexes were examined. Thyroid nodules were diagnosed by ultrasonography. Patients were randomly divided into intervention group(n=300) and control group(n=700). Patients in intervention group received lifestyle intervention; all patients were followed up for 12 months, then were investigated again. Results There were no significant differences in clinical data and the prevalence of thyroid nodules at baseline between the two groups(χ2=2.224, P=0.636). More thyroid nodules developed in patients of control group than that those in intervention group by the end of 12-month follow-up(5.3% vs 2.0%, χ2=5.509, P=0.02). Pearson correlation analysis showed that correlations between FT3 and BMI, FT3 and HDL-C, BMI and TSH, TPOAb and fasting plasma glucose(FPG)(all P<0.05). Multivariate logistic regression analysis showed that age, BMI, FPG, HbA1c, TC, and TG were independent factors affecting the onset of thyroid nodules. Conclusion Thyroid nodules in patients with metabolic syndrome are associated with body weight, blood glucose and blood lipids. Therapeutic lifestyle intervention may reduce the prevalence of thyroid nodules.
