ZENG Rui-Xiang,ZHANG Bing-Yu,SHU Xiao-liang,et al.Serum 25-hydroxy vitamin D level and its influencing factors in middle-old aged patients with type 2 diabetes[J].同济大学学报（医学版）,2017,38(2):84-88, 94. [点击复制]
Serum 25-hydroxy vitamin D level and its influencing factors in middle-old aged patients with type 2 diabetes
ZENG Rui-Xiang,ZHANG Bing-Yu,SHU Xiao-liang,LEI Tao
(Dept.of Endocrinology, Tongji Hospital, Tongji University, Shanghai 200065, China;Dept.of Nutritional, Jinshan Hospital, Fudan University, Shanghai 201508, China;Dept.of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China)
Abstract:
Objective To investigate the serum 25-hydroxy vitamin D level and its influencing factors in middle-old aged patients with type 2 diabetes(T2DM). Methods Total 548 middle-old aged patients with type 2 diabetes(280 males and 268 females) and 120 healthy subjects(60 males and 60 females) were enrolled in the study. Fasting blood samples were collected and serum 25-hydroxy vitamin D, Ca, P, FINS, FPG, HbA1c, TG, TC, LDL-C, HDL-C were measured. ResultsSerum 25-hydroxy vitamin D in diabetic patients was(36.89±16.82)nmol/L, and that in healthy controls was (45.84±17.68)nmol/L(P＜0.05). The mean serum 25-hydroxy vitamin D level in male diabetic patients was higher than that in female patients[(38.09±16.58)nmol/L vs(35.63±16.26)nmol/L,P＜0.05]. Serum 25-hydroxy vitamin D level in male patients was significantly higher than female patients in all age group except 50-59(P＜0.05). In male patients, 25-hydroxy vitamin D level in age group ≥70 was the highest, that in age group 40-49 was the lowest, there were significant difference among different age group(F=17.68,P＜0.01). In female patients, 25-hydroxy vitamin D level in age group ≥70 was the highest, that in age group 40-49 was the lowest, there were significant difference among different age groups(F=13.43,P＜0.01). The 25-hydroxy vitamin D deficiency rate in T2DM patients was 58.39%(60.82% for female and 56.07% for male, P＜0.01). 25-hydroxy vitamin D was positively correlated with Ca(r=0.072)and HOMA-β(r=0.406)(both P＜0.05), and negatively correlated with BMI(r=-0.574), P(r=-0.098), TC(r=-0.401), TG(r=-0.325), LDL-C(r=-0.457), FPG(r=-0.238), HbA1c(r=-0.363) and HOMA-IR(r=-0.251)(all P＜0.05). ConclusionSerum 25-hydroxy vitamin D concentration in middle-old aged patients with type 2 diabetes is significantly lower than in healthy subjects, and influenced by age, gender, serum Ca, P, blood glucose, cholesterol and pancreas islet function.
