| 摘要: |
| 目的 探讨血清三叶因子-3(trefoil factor-3, TFF-3)和半乳糖凝集素-3(Galectin-3)在甲状腺肿瘤中的表达及在甲状腺良恶性肿瘤鉴别诊断中的意义。方法 选择2014年1月至2015年12月在我院就诊的甲状腺乳头状癌患者110例,为甲状腺乳头状癌组。选择同期在我院就诊甲状腺腺瘤患者40例,为甲状腺腺瘤组。选择同期在我院行健康体检者30例,为健康对照组。用酶联免疫吸附法检测各组TFF-3和Galectin-3水平。观察甲状腺乳头状癌组,甲状腺腺瘤组和健康对照组血清TFF-3和Galectin-3,甲状腺乳头状癌患者血清TFF-3和Galectin-3水平与临床病理因素的关系,手术后机体TFF-3和Galectin-3水平的变化,及TFF-3和Galectin-3水平相关性分析。结果 甲状腺乳头状癌组血清TFF-3水平明显低于甲状腺瘤组和健康对照组(P<0.01),甲状腺瘤组低于健康对照组(P<0.01),而甲状腺乳头状癌组的Galectin-3表达水平明显高于甲状腺腺瘤组和健康对照组(P<0.01),而甲状腺腺瘤组明显高于健康对照组最低(P<0.01)。甲状腺乳头状癌患者血清TFF-3和Galectin-3水平与肿瘤直径,肿瘤分期,肿瘤分级和肿瘤是否淋巴结转移具有明显相关性(P<0.05或<0.01),与年龄,性别,肿瘤是否侵犯包膜和远处转移无明显相关性(P>0.05),甲状腺癌根治术后血清TFF-3较手术前明显升高(P<0.01),而Galectin-3水平较治疗前明显降低(P<0.01)。甲状腺乳头状癌患者的血清TFF-3水平与Galectin-3水平呈明显的负相关(r=-0.737,P<0.05)。结论 TFF-3和Galectin-3参与了甲状腺肿瘤的发生发展过程,其在甲状腺良恶性肿瘤鉴别诊断上具有重要意义。 |
| 关键词: 三叶因子-3 半乳糖凝集素-3 甲状腺乳头状肿瘤 鉴别诊断 |
| DOI：10.16118/j.1008-0392.2016.06.023 |
| 投稿时间：2015-07-26 |
| 基金项目: |
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| Trefoil factor-3 and galectin-3 in differential diagnosis of benign and malignant thyroid tumors |
| WANG Wei-jian,ZHENG Feng |
| (Dept. of General Surgery, Shanghai Electric Power Hospital, Shanghai 200050, Chian) |
| Abstract: |
| Objective To investigate the serum levels of trefoil factor-3(TFF-3) and Galectin-3 in differential diagnosis of benign and malignant thyroid tumors. Methods One hundred and ten patients with papillary thyroid carcinoma, 40 patients with thyroid adenoma admitted from January 2014 to December 2015, and 30 healthy subjects(controls) were enrolled in the study. Serum TFF-3 and Galectin-3 levels were measured by enzyme-linked immunosorbent assay. The relationship of TFF-3 and Galectin-3 levels with clinicopathological features were analyzed in patients with papillary thyroid cancer, their post-operative levels of TFF-3 and Galectin-3 were also measured. Results The serum TFF-3 levels were significantly lower in papillary thyroid carcinoma patients than those in thyroid adenoma patients and healthy controls, while the Galectin-3 levels in papillary thyroid carcinoma group were significantly higher than those in thyroid adenoma group and healthy control group(P<0.01), and those in thyroid adenoma group were significantly higher compared with the healthy control group(P<0.01). Serum TFF-3 and Galectin-3 levels were significantly correlated with tumor size, tumor stage, tumor grade and lymph node metastasis in patients with thyroid papillary carcinoma(P<0.05 or<0.01), but not correlated with age, sex, membrane invasion and distant metastasis(P>0.05). After thyroid cancer radical surgery the serum TFF-3 levels increased and Galectin-3 levels significantly decreased than those before surgery(P<0.01). Serum TFF-3 level was negatively correlated with Galectin-3(r=-0.737, P<0.05) in patients with papillary thyroid carcinoma. Conclusion TFF-3 and Galectin-3 may be involved in the development of thyroid tumor, they are of value in the differential diagnosis of benign and malignant thyroid tumors. |
| Key words: trefoil factor-3 galectin-3 papillary thyroid carcinoma differential diagnosis |
