| 引用本文： |
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赵炎平,孙宏伟,翟小贺.电针干预治疗原发性骨质疏松症的临床疗效观察[J].同济大学学报（医学版）,2016,37(6):93-96, 110. [点击复制]
- ZHAO Yan-ping,SUN Hong-wei,ZHAI Xiao-he.Clinical observation on the treatment of primary osteoporosis with electro acupuncture[J].同济大学学报（医学版）,2016,37(6):93-96, 110. [点击复制]
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| 摘要: |
| 目的 观察电针干预治疗原发性骨质疏松症(primary osteoporosis, POP)对Ⅰ型胶原N前端肽(prcollagen Ⅰ N-terminal propeptide, PINP)、Ⅰ型胶原C末端肽(collagen type Ⅰ C-terminal cross-linked telopeptide, CTX)、骨密度(bone mineral density, BMD)和症状积分的影响。方法 按随机对照原则,入组病例分治疗组35例、对照组35例。治疗组口服仙灵骨葆胶囊基础上加电针治疗,对照组口服仙灵骨葆胶囊。两组均治疗3个月,治疗结束后6个月时随访。对比分析不同时间点的疗效指标。结果 组间比较治疗前2组样本疗效指标,差异无统计学意义(P>0.05)。PINP于治疗结束时、治疗结束后6个月时组间、组内比较,差异有统计学意义(P<0.05)。CTX于治疗结束时、治疗结束后6个月时组间比较,差异无统计学意义(P>0.05),组内比较,治疗组差异有统计学意义(P<0.05),对照组差异无统计学意义(P>0.05),各组治疗前后差值比较有统计学意义(P<0.05)。BMD、症状积分数据组间、组内比较,BMD差异无统计学意义(P>0.05),症状积分差异有统计学意义(P<0.05)。Ridit分析,R治疗组=0.5993,R对照组=0.4006,u=3.643(P<0.05),治疗组疗效优于对照组。结论 电针治疗POP肝肾不足证能促进PINP生成,抑制CTX产生,BMD变化短期不够灵敏,症状积分变化明显。 |
| 关键词: 电针 原发性骨质疏松症 Ⅰ型胶原N前端肽 Ⅰ型胶原C末端肽 骨密度 症状积分 |
| DOI：10.16118/j.1008-0392.2016.06.018 |
| 投稿时间：2016-06-07 |
| 基金项目: |
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| Clinical observation on the treatment of primary osteoporosis with electro acupuncture |
| ZHAO Yan-ping,SUN Hong-wei,ZHAI Xiao-he |
| (Dept.of Orthopedics, Shanghai Yangpu Hospital of Traditional Chinese Medicine, Shanghai 200090, China;Shanghai Yangpu Hospital of Traditional Chinese Medicine, Orthopedics, Shanghai 200090, China;Dept.of Pharmacy, Shanghai Yangpu Hospital of Traditional Chinese Medicine, Shanghai 200090, China) |
| Abstract: |
| Objective To evaluate the efficacy of electroacupuncture for primary osteoporosis. Methods Seventy primary osteoporosis patients with “liver and kidney deficiency” diagnosed according to TCM symptom differentiation were randomly divided into two groups with 35 cases in each. Patients in therapy group received electroacupuncture and oral Chinese medicine Xianlinggubao capsule, while those in control group received oral Xianlinggubao capsule alone. Both groups were treated for 3 months and followed up after 6 month. Serum prcollagen Ⅰ N-terminal propeptide(PINP), collagen type Ⅰ C-terminal cross-linked telopeptide(CTX), bone mineral density(BMD) were measured and symptom scores were assessed before and after treatment in both groups. The curative effect at different time points were analyzed and compared between two groups. Results There were no differences in PINP, CTX, BMD and symptom scores between two groups before treatment(P>0.05). By the end of treatment and at 6 months follow-up, differences in PINP within and between two groups showed statistical significance(P<0.05). There was significant difference in CTX of therapy group before and after treatment(P<0.05), but not in the control group(P>0.05). There were no significant differences in BMD within and between two groups before and after treatment(P>0.05), while symptom score showed statistical significance(P<0.05). Ridit analysis showed that the efficacy of therapy group was better than that of control group(R=0.5993 vs 0.4006,u=3.643, P<0.05). Conclusion Electroacupuncture combined with oral Xianlinggubao capsule is effective in treatment of primary osteoporosis patients with Liver and Kidney Deficiency. |
| Key words: electroacupuncture primary osteoporosis prcollagen Ⅰ N-terminal propeptide collagen type Ⅰ C-terminal cross-linked telopeptide bone mineral density symptom score |
