引用本文: |
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罗云,顾亚萍,廖小平.SCH患者左甲状腺片替代治疗前后动脉粥样硬化危险因素的变化[J].同济大学学报(医学版),2016,37(6):54-58. [点击复制]
- LUO Yun,GU Ya-ping,LIAO Xiao-ping.Changes of atherosclerosis risk factors in patients with subclinical hypothyroidism after levothyroxine replacement therapy[J].同济大学学报(医学版),2016,37(6):54-58. [点击复制]
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摘要: |
目的 观察亚临床甲状腺功能减退左甲状腺素片替代治疗前后动脉粥样硬化危险因素的变化。方法 根据TSH将研究对象分为三组: 对照组: 0.4mU/L10mU/L。比较三组间动脉粥样硬化危险因素(BMI、TC、TG、LDL-C、HDL-C、SBP、DBP、HBA1C、HCY、baPWV、baABI)的差异,并对A、B两组行左甲状腺素片替代治疗3个月,比较替代治疗后上述危险因素的变化。结果 A、B两组的BMI、TC、TG、LDL-C、HCY、baPWV较健康对照组显著升高,HDL-C显著降低(P<0.05),B组的TG、LDL-C、HCY、baPWV较A组进一步升高,HDL-C进一步降低(P<0.05)。经过替代治疗后,A组TSH、TC、HCY、baPWV较治疗前显著降低(P<0.05)。B组TSH、BMI、TC、TG、LDL-C、HCY、baPWV较治疗前显著降低(P<0.05)。以baPWV作为应变量,其他危险因素为自变量行多元逐步回归分析,提示baPWV与TSH、TC、LDL-C、HDL-C、HCY独立相关,与其他因素无关。结论 亚临床甲减存在多种动脉粥样硬化、心脑血管疾病的高危因素,TSH轻度升高阶段便可采用小剂量左旋甲状腺素钠替代治疗,从而改善血脂异常、防止动脉硬化症,以减少心血管疾病的发生。 |
关键词: 亚临床甲状腺功能减退 动脉粥样硬化 左甲状腺素钠 替代治疗 |
DOI:10.16118/j.1008-0392.2016.06.010 |
投稿时间:2016-04-18 |
基金项目: |
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Changes of atherosclerosis risk factors in patients with subclinical hypothyroidism after levothyroxine replacement therapy |
LUO Yun,GU Ya-ping,LIAO Xiao-ping |
(Dept. of Endocrinology, Anting Hospital, Jiading, Shanghai 201805, China) |
Abstract: |
Objective To observe the changes of atherosclerosis risk factors in patients with subclinical hypothyroidism after levothyroxine replacement therapy. Methods Eighty patients with subclinical hypothyroidism(SCH) including 48 cases with 4mU/L10mU/L(group B), and 40 normal subjects with 0.4mU/L
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Key words: subclinical hypothyroidism atherosclerosis levothyroxine replacement therapy |