| 摘要: |
| 胰腺导管腺癌(pancreatic ductal adenocarcinoma, PDAC)是最常见的胰腺癌病理类型,亦是预后最差的恶性肿瘤。近年来胰腺肿瘤干细胞(pancreatic cancer stem cell, PCSC)的研究取得了诸多进展,PCSC与胰腺肿瘤的侵袭、转移及复发都有着直接联系。本研究将从PCSC的相关标志物、肿瘤微环境及靶向治疗等角度对近年来PCSC的相关研究进展作一综述。 |
| 关键词: 胰腺肿瘤 肿瘤干细胞 标志物 肿瘤微环境 |
| DOI：10.16118/j.1008-0392.2016.04.024 |
| 投稿时间：2015-05-30 |
| 基金项目:上海浦东新区卫生系统领先人才(PWR12012-01) |
|
| Advance in pancreatic cancer stem cell research |
|
| (Dept. of Geriatric Medicine, East Hospital, Tongji University, Shanghai 200120, China) |
| Abstract: |
| Pancreatic ductal adenocarcinoma(PDAC) is the most common histopathological type of pancreatic cancer with a poor prognosis. Pancreatic cancer stem cell(PCSC) are considered a direct connection with the invasion, metastasis and recurrence of PDAC. This article reviews the recent research progress on the bio-markers, tumor microenvironment of PCSC and it's potential application in targeted therapy. |
| Key words: pancreatic cancer cancer stem cells bio-markers tumor microenvironment |
