| 引用本文： |
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陆晶晶,黄建浩,尹琦,等.烟碱型乙酰胆碱受体基因多态性与NSCLC的相关性研究[J].同济大学学报（医学版）,2016,37(3):36-39, 55. [点击复制]
- LU Jing-jing,HUANG Jian-hao,YIN Qi,et al.Association between CHRNA5 gene polymorphism and susceptibility to non-small cell lung cancer[J].同济大学学报（医学版）,2016,37(3):36-39, 55. [点击复制]
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| 摘要: |
| 目的 探讨烟碱型乙酰胆碱受体a5(nicotine acetylcholine receptor subunits alpha5, CHRNA5)基因-1640 C/T(rs3829787)单核苷酸多态性与非小细胞肺癌(non-small cell lung cancer, NSCLC)易感性的关系。方法 应用聚合酶链式反应和Sanger测序方法,检测102例非小细胞肺癌患者和131例健康对照者CHRNA5基因-1640C/T位点基因型分布情况,观察该位点基因多态性是否与非小细胞肺癌发病及病理类型相关。结果 两组人群均存在CHRNA5基因-1640C/T多态性；两组人群基因型、等位基因频率差异存在统计学意义,肺癌组CT+TT基因型、T等位基因频率均高于对照组(P＜0.05)；基因型频率的相对风险分析发现,CT、TT基因型各自患肺癌的风险分别是CC基因型的1.77倍(95%CI: 0.93～3.36)和4.70倍(95%CI: 1.23～17.99)；-1640T在肺腺癌中分布频率较非腺癌中高(P＜0.05)。结论 CHRNA5基因-1640C/T多态性可能与非小细胞肺癌易感性相关,该位点携带T等位基因的吸烟人群可能更容易发生肺癌,尤其是肺腺癌。 |
| 关键词: 非小细胞肺肿瘤 烟碱型乙酰胆碱受体a5基因 单核苷酸多态性 等位基因 |
| DOI：10.16118/j.1008-0392.2016.03.007 |
| 投稿时间：2015-08-07 |
| 基金项目:同济大学附属东方医院起航计划青年项目(DFQH-Q18) |
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| Association between CHRNA5 gene polymorphism and susceptibility to non-small cell lung cancer |
| LU Jing-jing,HUANG Jian-hao,YIN Qi,ZHU Hui |
| (Dept. of Respiratory Medicine, East Hospital, Tongji University, Shanghai 200120, China) |
| Abstract: |
| Objective To investigate the association of nicotine acetylcholine receptor subunits alpha 5 (CHRNA5) gene-1640C/T (rs3829787)polymorphism with susceptibility to non-small cell lung cancer (NSCLC). Methods CHRNA5 gene-1640C/T polymorphism was genotyped with PCR-Sanger method in 102 NSCLC patients and 131 healthy adults. The association of CHRNA5 gene polymorphism with pathological type of lung cancer was analyzed. Results CHRNA5 gene-1640 CT+TT genotype and T allele were more frequent in NSCLC patients than that in controls (P＜0.01). The relative risk of CT genotype carrier to NSCLC was 1.77 times of CC genotype (95%CI: 0.93-3.36). The relative risk of TT genotype carrier to NSCLC was 4.70 times of CC genotype (95%CI: 1.23-17.99). The distribution of CHRNA5 gene-1640T polymorphism in lung adenocarcinoma was higher than that of non-adenocarcinoma. Conclusion CHRNA5 gene-1640T allele may be a genetic susceptibility factor to NSCLC,especially to lung adenocarcinoma. |
| Key words: non-small cell lung cancer nicotine acetylcholine receptor subunits alpha 5 gene single nucleotide polymorphism allele |
