| 引用本文： |
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杨君君,彭生,张晓庆.磷酸肌酸钠对老年患者全身麻醉术后认知功能障碍的影响[J].同济大学学报（医学版）,2015,36(3):96-100. [点击复制]
- YANG Jun-jun,PENG Sheng,ZHANG Xiao-qing.Creatine phosphate sodium improves postoperative cognitive function in elderly patients undergoing total hip joint replacement under general anesthesia[J].同济大学学报（医学版）,2015,36(3):96-100. [点击复制]
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| 摘要: |
| 目的 探讨磷酸肌酸钠对老年患者全身麻醉下行全髋关节置换术后认知功能障碍的影响。方法选择全身麻醉下择期行全髋关节置换手术ASA1～2级的老年患者80例,年龄70～90岁,随机分为两组,磷酸肌酸钠组(40例)和对照组(40例)。磷酸肌酸钠组分别在全麻插管后、术后24、48、72h分别将磷酸肌酸钠1g溶入100ml的生理盐水中30min内静脉点滴完毕,对照组在同样的时间点静脉点滴等容积生理盐水。两组麻醉诱导方法及维持用药相同。两组所有患者分别于术前、术毕30min和术毕12h从颈内静脉抽取3ml血液,采用ELISA法测定血清NSE和S100β蛋白含量。并于麻醉前和术后第4d和7d应用简易智力状态量表(MMSE)和韦氏记忆量表(WMS)评估术后认知功能。结果 两组患者术前血清NSE和S100β蛋白含量组间差异无统计学意义(P＞0.05)。磷酸肌酸钠组术毕30minS100β蛋白含量和术毕12h血清NSE含量均明显低于对照组,差异有统计学意义(P＜0.05)。术前MMSE和WMS评分组间差异无统计学意义(P＞0.05)。磷酸肌酸钠组MMSE和WMS评分在术后第4d和7d时均明显高于对照组,差异有统计学意义(P＜0.05)。结论应用磷酸肌酸钠能提高老年患者全身麻醉下行全髋关节置换术后早期认知功能。 |
| 关键词: 磷酸肌酸钠 老年患者 全身麻醉 术后认知功能障碍 |
| DOI：10.16118/j.1008-0392.2015.03.021 |
| 投稿时间：2014-09-17 |
| 基金项目: |
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| Creatine phosphate sodium improves postoperative cognitive function in elderly patients undergoing total hip joint replacement under general anesthesia |
| YANG Jun-jun,PENG Sheng,ZHANG Xiao-qing |
| (Dept. of Anesthesiology, Tongji Hospital, Tongji University, Shanghai 200065, China) |
| Abstract: |
| Objective To evaluate the effects of creatine phosphate sodium on postoperative cognitive function in elderly patients undergoing total hip joint replacement under general anesthesia. MethodsEighty ASA 1-2 elderly patients scheduled for selective total hip joint replacement under general anesthesia, aged 70-90 years, were randomly divided into creatine phosphate sodium group (CPS group) and control group (n=40 in each):patients in CPS group were given 1.0g of creatine phosphate sodium intravenously 30 min after endotracheal intubation, at 24,8,72h postoperatively; patients in control group were given the same-volume of saline instead. Anesthesia was maintained with the same inhalation and intravenous anesthetics in both groups. The levels of serum NSE and S100β were detected in all patients preoperatively and at 30min and 12h postoperatively. All patients were tested with mini-mental state examination (MMSE) and WMS, preoperatively and on d 4 and d 7 postoperatively. Results There was no significant difference in the levels of serum NSE and S100β between CPS group and control group preoperatively (P＞0.05).Compared with control group, the level of serum NSE at 12h after operation and the level of serum S100β at 30min after operation in CPS group were significantly lower (P＜0.05). There was no significant difference in the scores of MMSE and WMS between two groups preoperatively (P＞0.05). Compared with control group, the scores of MMSE and WMS in CPS group was significantly higher on d 4 and d 7 postoperatively (P＜0.05). Conclusion Creatine phosphate sodium can reduce the incidence of postoperative cognitive dysfunction in elderly patients undergoing total hip joint replacement under general anesthesia. |
| Key words: creatine phosphate sodium elderly patients general anesthesia postoperative cognitive dysfunction |
