| 引用本文： |
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陈胜,闵红叶,李宏,等.体质量在兔窒息心跳骤停模型中对诱导亚低温的影响[J].同济大学学报（医学版）,2015,36(1):42-45, 57. [点击复制]
- CHEN Sheng,MIN Hong-ye,LI Hong,et al.Effect of body weight on the induction of mild hypothermia by two different methods in a rabbit model of asphyxia cardiac arrest[J].同济大学学报（医学版）,2015,36(1):42-45, 57. [点击复制]
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| 摘要: |
| 目的观察体质量在兔窒息心跳骤停模型中对两种诱导亚低温方法的影响。方法体质量1000~2500g兔24只麻醉后,随机分成冰袋组和4℃生理盐水组,夹闭气管法制造心跳骤停模型。心跳骤停后3min开始心肺复苏,同时分别采用冰袋放在动物的上腹或耳缘静脉输注4℃生理盐水的方法诱导亚低温；定义直肠温度降低2℃为诱导亚低温完成。采用t检验比较两组诱导亚低温所需时间,并用Pearson相关检验分析两组诱导亚低温所需时间与体质量的关系。结果 所有动物均达到自主循环重建,且自主循环重建持续至实验结束。冰袋组诱导亚低温所需时间显著短于4℃生理盐水组[(22.8±4.7)min vs(42.5±4.0)min, P＜0.001]。冰袋组诱导亚低温所需时间与体质量正相关(r=0.725, P=0.029),但4℃生理盐水组诱导亚低温所需时间与体质量不相关(r=0.342, P=0.418)。结论 兔心跳骤停模型中,诱导亚低温用冰袋快于静脉输注4℃生理盐水。临床上早期诱导亚低温选择方法时需要考虑体质量的影响。 |
| 关键词: 心跳骤停 心肺复苏 亚低温 体质量 |
| DOI：10.16118/j.1008-0392.2015.01.010 |
| 投稿时间：2014-08-08 |
| 基金项目: |
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| Effect of body weight on the induction of mild hypothermia by two different methods in a rabbit model of asphyxia cardiac arrest |
| CHEN Sheng,MIN Hong-ye,LI Hong,CHEN Yan-qing,ZHUANG Yu-gang,PENG Hu |
| (Dept. of Emergency, Tenth People's Hospital, Tongji University, Shanghai 200072, China) |
| Abstract: |
| Objective To investigate the effect of body weight on the induction of mild hypothermia by two different methods in a rabbit model of asphyxia cardiac arrest. MethodsTwenty four anaesthetized rabbits weighted 1000-2500g were randomized into two groups: one treated with an ice bag and the other treated with intravenous 4℃ saline for induction of mild hypothermia. Cardiac arrest was induced by clamping endotracheal tube. After 3min of cardiac arrest, cardiopulmonary resuscitation was begun. Simultaneously, mild hypothermia was induced by putting an ice bag over the abdomen or infusion of 4℃ saline via ear vein. 2℃ decrease of rectal body temperature was considered as the completion of hypothermia induction. Induction times were compared by t test, and analyzed with respect to body weight by Pearson correlation. ResultsAll rabbits had restoration of spontaneous circulation and it lasted through the experiments. Induction time in the ice bag group was significantly shorter than that in the intravenous 4℃ saline group(22.8±4.7min vs 42.5±4.0min, P＜0.001). There was a significant correlation between induction time and body weight in the ice bag group(Pearson Correlation: r=0.725, P=0.029), but no significant correlation was observed between induction time and body weight in the intravenous 4℃ saline group(Pearson Correlation: r=0.342, P=0.418). ConclusionIn a rabbit model, induction of mild hypothermia with an ice bag is faster than that with intravenous 4℃ saline. The effect of body weight should be considered when choosing an appropriate method to achieve early induction of mild hypothermia. |
| Key words: cardiac arrest cardiopulmonary resuscitation mild hypothermia body weight |
