| 摘要: |
| 术后认知功能障碍（postoperative cognitive dysfunction,POCD）是发生在手术麻醉以后的可逆性或长期存在的严重并发症,好发于老年人群。POCD需要与痴呆和术后谵妄相鉴别。近年来,许多危险因素被认为与POCD的发生有关,然而其确切的病因仍未知。本文就POCD诊断、发病机制和治疗方面的进展进行综述。 |
| 关键词: 术后认知功能障碍 谵妄 痴呆 神经炎症 凋亡 突触 |
| DOI：10.3969/j. issnl008 - 0392.2014.05.027 |
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| 基金项目:上海市浦东新区卫生系统重点专科（PWZz2013-17）; 上海市浦东新区科委科技发展创新基金（PKJ2011-Y37） |
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| Progress in postoperative cognitive dysfunction studies |
| ZHAO Yu-peng,WANG Qing-xiu |
| (Dept. of Anesthesiology, East Hospital, Tongi University, Shanghai 200120, China) |
| Abstract: |
| Postoperative cognitive dysfunction（ POCD） is a severe transient or long-term complication after surgical procedures and anesthesia,especially in the elderly population. POCD should be distinguished from dementia or acute postoperative delirium. M ultiple risk factors have been identified over the last decade. However,the exact etiology is still unknown. This article reviews the recent progress concerning diagnosis,potential mechanisms and treatment of POCD. |
| Key words: postoperative cognitive dysfunction delirium dementia neuroinflammation apoptosis synapse |
