| 摘要: |
| 盐霉素在过去30多年中被广泛应用于防治家禽的球虫病和提高反刍动物的饲料吸收率。2009年,研究者首先发现盐霉素可以选择性的杀伤乳腺癌肿瘤干细胞,且其效率比紫杉醇高出100多倍。此后,越来越多的研究者在体内、体外实验中发现盐霉素可以抑制多种肿瘤干细胞(结直肠癌肿瘤干细胞,肺癌肿瘤干细胞,胰腺癌肿瘤干细胞)的生长,克服肿瘤细胞由P53基因突变,Bcl-2、26S蛋白酶体、P-糖蛋白的过表达引起的凋亡抵抗,增加肿瘤细胞的DNA损伤,激活肿瘤细胞的氧化应激,抑制肿瘤细胞中Wnt信号通路的活性,此外盐霉素还可以增加肿瘤细胞对药物治疗的敏感性。所以盐霉素有希望成为一个新型的化疗药物被用于抗肿瘤的治疗中。 |
| 关键词: 盐霉素 肿瘤干细胞 凋亡 耐药 |
| DOI：10.3969/j.issn1008-0392.2013.03.033 |
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| 基金项目:国家自然科学基金（81072005）;国家自然科学基金（81101579） |
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| Salinomycin—a potential novel anticancer agent |
| WANG Fan,GUO Chuan-yong |
| (Dept.of Gastroenterology,Tenth People＇s Hospital,Tongji University,Shanghai 200072,China) |
| Abstract: |
| Salinomycin has been used as a veterinary antibiotic to prevent coccidiosis in poultry and to improve nutrient absorption in ruminants for more than 30 years.In 2009 researchers firstly found that salinomycin would selectively kill breast cancer stem cells,further studies revealed that salinomycin inhibited the growth of variety of cancer stem cells including colorectal,lung and pancreatic cancer stem cells.The agent can overcome the resistance of cancer cell apoptosis caused by P53 gene mutation,the over-expression of Bcl-2 protein,26S proteasome and P-glycoprotein;the agent can increase DNA damage,activate oxidative stress,inhibit Wnt signaling pathway and enhance the sensitivity of tumor cells to drug therapy.Salinomycin may be used as a novel chemotherapy drug in the future. |
| Key words: Salinomycin cancer stem cells apoptosis drug resistance |
