| 引用本文： |
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李琛,梁兴伦,朱敏洁.血糖波动对老年2型糖尿病患者颈动脉血管病变的影响[J].同济大学学报（医学版）,2013,34(2):82-85. [点击复制]
- LI Chen,LIANG Xing-lun,ZHU Min-jie.Blood glucose excursion on carotid atherosclerosis in elderly type 2 diabetic patients[J].同济大学学报（医学版）,2013,34(2):82-85. [点击复制]
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| 摘要: |
| 目的探讨血糖波动对老年2型糖尿病（T2DM）患者颈动脉血管病变的影响。方法选取老年2型糖尿病患者123例，根据颈动脉有无病变分为A组（颈动脉无病变组）和B组（有病变组）。所有患者均接受3d动态血糖检测（CGMS），计算平均空腹血糖（MFBG）、平均餐后2h血糖（MPBG）、平均血糖水平（MBG）、血糖水平标准差（SDBG）、平均血糖漂移幅度（MAGE）、血糖波动最大幅度（LAGE）、低血糖时间比（血糖〈3.9mmol/L），并检测血压、血脂、糖化血红蛋白（HbAlc）。结果两组间性别、胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、三酰甘油水平差异无统计学意义（P＞0.05）。B组病程、血压、低密度脂蛋白胆固醇（LDL-C）、HbAlc、MAGE、SD、LAGE、MPBG、低血糖时间均高于A组，差异有统计学意义（P＜0.05）。结论老年2型糖尿病患者的颈动脉血管病变不仅与血压、血糖、血脂、HbAlc有关，而且和血糖波动密切相关，血糖波动大的患者发生慢性并发症的危险性高。 |
| 关键词: 2型糖尿病 血糖波动 动态血糖监测 颈功脉血管病变 |
| DOI：10.3969/j.issn1008-0392.2013.02.020 |
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| 基金项目: |
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| Blood glucose excursion on carotid atherosclerosis in elderly type 2 diabetic patients |
| LI Chen,LIANG Xing-lun,ZHU Min-jie |
| (Dept. of Geriatrics, Central Hospital of Yangpu District, Shanghai 200093, China) |
| Abstract: |
| Objective To investigate the association between blood glucose excursion and carotid atherosclerosis in elderly type 2 diabetic patients. Methods Blood glucose levels were monitored with a continuous glucose monitoring system （CGMS） for 3 days in 123 elderly patients with type 2 diabetes. The carotid intimate media thickness （IMT） was observed by Doppler ultrasonography and patients were divided into two groups： group A without carotid lesions and group B with carotid lesions. The mean fasting blood glucose （MFBG）, mean postprandial blood glucose （MPBG）, mean blood glucose （MBG）, standard deviation of blood glucose （SDBG）, mean amplitude of glycemic excursion （MAGE）, largest amplitude of glycemic excursion （LAGE） time of low blood glucose （〈3.9 mmol/L） were examined and blood pressure （BP）, serum lipids,HbAlc were also measured. Results The duration of diabetes, blood pressure （BP）, low density lipoprotein cholesterol （LDL-c） and HbAlc in group B were higher than those in group A. The MAGE, SD, LAGE, MPBGand time of low glucose in group B were significantly increased compared to group A （P＜0.01 ）. Conclusion Carotid atherosclerosis was not only associated with blood pressure, blood glucose, serum lipid profile and HbAlc; but also closely correlated with the range of blood glucose excursion in elderly type 2 diabetic patients. Patients with a larger range of blood glucose excursion have higher risks for developing chronic complications. |
| Key words: type 2 diabetes mellitus glucose excursion continuous glucose monitoring system carotid atherosclerosis |
