| 引用本文： |
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蒋海弦,李天舒,周鸣清.胆结石患者血浆脂多糖与胆源性胰腺炎的关系[J].同济大学学报（医学版）,2013,34(2):78-81. [点击复制]
- JIANG Hai-xian,LI Tian-shu,ZHOU Ming-qing.Relation between plasma lipopolysaccharide and biliary pancreatitis in patients with gallstone[J].同济大学学报（医学版）,2013,34(2):78-81. [点击复制]
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| 摘要: |
| 目的探讨血浆脂多糖（1ipopolysaccharide，LPS）与胆源性胰腺炎发生的关系。方法选取胆结石患者（包括胆囊、胆管结石）共60例，并依据血浆LPS水平，分为低LPS组（〈10pg/ml，n=24）与高LPS组（≥10pg/ml，n=36），并随访12个月，分析不同LPS水平的胆结石患者胆源性胰腺炎的发生率。结果最终纳入分析51例，低LPS组20例，高LPS组31例。两组间年龄，性别构成，血脂水平（TG、TCH），基础炎症水平（WBC、CRP），空腹血糖（BS）差异均无统计学意义（P＞0.05）。高LPS组患者发生胆源性急性胰腺炎风险为低LPS组的2.021倍，差异有统计学意义（RR=2.021，95%CI1.006~4.058，P=0.02），且LPS导致不同TG水平胆道结石患者发生胆源性急性胰腺炎的风险差异无统计学意义（P＞0.05）。在细小结石（＜0.4cm×0.3cm）患者中，高LPS组患者发生胆源性急性胰腺炎风险为低LPS组的2.327倍，差异有统计学意义（RR=2.327，95%CI1.030~5.259．P=0.03）。结论血浆LPS水平的增高是高TG水平与细小胆囊结石患者易发生胆源性胰腺类的因素之一。 |
| 关键词: 脂多糖 胆源性胰腺炎 诊断 |
| DOI：10.3969/j.issn1008-0392.2013.02.019 |
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| 基金项目: |
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| Relation between plasma lipopolysaccharide and biliary pancreatitis in patients with gallstone |
| JIANG Hai-xian,LI Tian-shu,ZHOU Ming-qing |
| (Dept. of General Surgery, Central Hospital of Zhabei District, Shanghai 200436, China) |
| Abstract: |
| Objective To investigate the correlation of plasma lipopolysaccharide （LPS） and incidence of biliary pancreatitis. Methods A total of 60 patients with gallstone were included in the present study, who were divided into low-LPS （〈10 pg/ml, n=24） and high-LPS （≥ 10 pg/ml, n=36） cohorts. After 12-month following up, the incidence of biliary pancreatitis was compared between two cohorts. Results There were finally 51 patients eligible for the data analysis, including 20 cases in low-LPS cohort and 31 cases in high-LPS cohort. There were no differences between two cohorts in age, gender, cholesterol （TG, TCH）, inflammatory reaction （WBC, CRP） and fasting blood-glucose （BS）. In patients with high TG level （≥5.65 mmol/L）, the incidence rates of biliary pancreatitis in high LPS group were higher than that in low LPS group （16/19 vs 5/12, odds ratio=2.021, 95%CI： 1.006-4.058, P=0.02）. There was no difference in risk of biliary pancreatitis between high and low TG groups in patients with high LPS （P＞0.05 ）. In patients with smallgallstone （〈0.4 x0.3 cm）, the risk of pancreatitis in high LPS patients was higher than that in low LPS patients （11/19 vs 4/11, odds ratio=2.327, 95% CI： 1.030-5.259, P=0.03）. Conclusion In patients with gallstone （especially small gallstone） and with high TG, the increase in plasma LPS concentration would results in a higher probability of biliary pancreatitis. |
| Key words: lipopolysaccharide biliary pancreatitis diagnosis |
