| 摘要: |
| 自噬是指细胞受到刺激后吞噬自身的细胞质或细胞器,最终将吞噬物在溶酶体内降解的过程。自噬作为细胞的一种程序性死亡方式,与凋亡有联系也有区别。自噬的分子诱导机制非常复杂且具有高度的保守性,其可能与PI3K-Akt-mTOR信号转导通路、Ⅲ型PI3K复合物、RAS-RAF-1-MEK-ERKl/2信号转导通路等有关。自噬发挥抑制肿瘤作用的分子机制尚不清楚,越来越多的证据提示自噬的抑癌作用可能与其潜在的促死亡和促生存效应有关。 |
| 关键词: 自噬 调节机制 肿瘤 |
| DOI：10.3969/j.issn1008 -0392.2012.05.027 |
| 投稿时间：2011-10-09 |
| 基金项目:国家自然科学基金（81072005);上海市科委项目（09410705400，10ZR1423300) |
|
| Autophagy and its role in oncogenesis |
| CHEN Cong-ying |
| (Dept.of Gastroenterology,Tenth People’s Hospital,Tongji University,Shanghai 200072,China) |
| Abstract: |
| Autophagy is a process by which stimulated cells phogocytize own intracellular cytoplasm or organelles and eventually are degraded in lysosomes. Both being patterns of programmed cell death, there are similarities as well as differences between autophagy and apoptosis. The regulatory mechanisms of autophagy are very complex and highly conserved, which may be associated with PI3K-Akt-mTOR, class III PI3K complex and RAS-RAF^-MEK- ERKl/2 signaling translations. Currently it is revealed that there are several genetic links between autophagy defects and cancer. However, the molecular mechanisms by which autophagy functions in tumor suppression are poorly defined. Increasing evidence suggests that the tumor suppressor functions of autophagy may be related to both its potential prodeath and prosurvival effects. |
| Key words: utophagy regulatory mechanism neoplasm |
