| 引用本文： |
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张庆慧,陈玲,顾金花,等.血清中幽门螺杆菌CagA抗体在东亚三国胃癌诊断中作用的meta分析[J].同济大学学报（医学版）,2012,33(5):105-109. [点击复制]
- ZHANG Qing-hui,CHEN Ling,GU Jin-hua,et al.Diagnosis of gastric cancer with serum anti-Helicobacter pylori CagA in three East Asian countries: a meta analysis[J].同济大学学报（医学版）,2012,33(5):105-109. [点击复制]
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| 摘要: |
| 目的系统评价血清中幽门螺杆菌CagA抗体对东亚三国胃癌的诊断价值。方法检索1990年1月至2012年1月万方数据、中国生物医学文献数据库、中国学术期刊全文数据库、Corhrance图书馆、PubMed、Embase及Web of Science数据库,应用STATA12.0及meta Disc 1.4软件对纳入研究进行综合定量评价,根据异质性结果选择相应效应模型进行定量合并,绘制受试者工作特征(summary receiver operating characteristic,SROC)曲线并计算曲线下面积(area under curve,AUC),进行敏感度分析。结果共纳入12篇中英文研究,累计病例1 524例,对照3327例,血清Cag A抗体阳性患者相对于抗体阴性OR值为1.90(95%CI:1.64～2.20,P=0.000),差异有统计学意义。血清幽门螺杆菌CagA抗体诊断胃癌的合并敏感性为0.71(95%CI:0.69～0.73),合并特异性为0.40(95%CI:0.39～0.42),SROC下面积为0.636。从研究国家进行分层分析,血清CagA抗体诊断胃癌在日本人群中敏感度更高(0.75,95%CI:0.72～0.77),而在中国人群中特异度更高(0.53,95%CI:0.50～0.56)。结论在东亚国家中,血清CagA抗体与胃癌关系极为密切,并对胃癌的诊断可能有重要的临床参考价值。 |
| 关键词: 幽门螺杆菌 胃肿瘤 诊断 meta分析 细胞毒素相关蛋白A抗体 |
| DOI：10.3969/j.issn1008 -0392.2012.05.025 |
| 投稿时间：2012-06-07 |
| 基金项目: |
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| Diagnosis of gastric cancer with serum anti-Helicobacter pylori CagA in three East Asian countries: a meta analysis |
| ZHANG Qing-hui,CHEN Ling,GU Jin-hua,LIU Yun,DUAN Hou-quan,YU Li-ya |
| (Dept.of Clinical Laboratory,Kunshan First People’s Hospital,Jiangsu University,Kunshan 215300,Jiangsu Province,China) |
| Abstract: |
| Objective To evaluate the diagnostic value of serum anti -Helicobacter pylori CagA for gastric cancer in East Asian countries. Methods Literatures on evaluation of serum anti -Helicobacter pylori CagA in diagnosis of gastric cancer in China, Japan and Korea published from January 1990 to January 2012 were searched from Wanfang Chinese Periodical Database, Chinese Bio-medicine Database (CBM) , China National Knowledge Infrastructure (CNKI) , Cochrane library, PubMed, Embase and Web of Science databases. Statistical analyses were performed with STATA12. 0 and meta Disc 1. 4 for sensitivity and specificity and Summary Receiver Operating Characteristic (SROC) curve was formed. Results Twelve studies with 1 524cases and 3 327 controls in three East Asia countries were included in this analysis. The pooled OR of positive serum CagA antibody compared to those of negative was 1. 90 (95% Cl： 1. 64 - 2. 20， P = 0. 000) . Sensitivity and specificity of serum CagA antibody for diagnosis of gastric cancer were 0. 71 (95% C/I 0. 69 -0. 73) and 0. 40 (95% CI： 0. 39 - 0. 42)，respectively. The area under SROC curve was 0. 636. Stratified analysis showed that the sensitivity of serum CagA antibody for diagnosis of gastric cancer in the Japanese population was highest (0. 75，95% C/： 0.72 -0.77)， and the specificity was highest in Chinese population (0. 53， 95% C/： 0. 50 - 0. 56). Conclusion Serum CagA antibody is associated with the risk of gastric cancer in East Asian countries， and may be of clinical value in diagnosis of gastric cancer. |
| Key words: helicobacter pylori gastric neoplasm diagnosis meta analysis cytotoxin associatedgene A antibody |
