| 引用本文： |
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赵邦凤,吴国亭.二甲双胍对2型糖尿病合并非酒精性脂肪肝患者肝脏脂肪含量的影响[J].同济大学学报（医学版）,2012,33(5):58-61. [点击复制]
- ZHAO Bang-feng,WU Guo-ting.Liver fat contents in type 2 diabetic patients with nonalcoholic fatty liver disease under metformin treatment[J].同济大学学报（医学版）,2012,33(5):58-61. [点击复制]
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| 摘要: |
| 目的探讨二甲双胍治疗对2型糖尿病(type 2 diabetes mellitus,T2DM)合并非酒精性脂肪肝(non-alcoholic fatty liver disease,NAFLD)患者肝脏脂肪含量变化的影响。方法采用磁共振波成像技术(magneticresonance spectroscopy,MRS)定量检测肝脏脂肪含量,脂峰下面积/(脂峰下面积+水峰下面积)大于5.5%认为具有脂肪肝。将T2DM合并NAFLD分为二甲双胍治疗组(A组,24例)和无二甲双胍治疗组(B组,24例),分析二甲双胍治疗T2DM合并NAFLD肝脏脂肪含量的变化,同时分析NAFLD患者的相关危险因素及临床特点。结果经二甲双胍治疗后,与B组相比,A组肝脏脂肪的含量有减少趋势,但差异无统计学意义(P>0.05);A组患者WC、BMI、FPG、HbA1c、TG明显减少,差异有统计学意义(P<0.05),AST、ALT等无明显变化(P>0.05)。结论二甲双胍不仅能改善T2DM合并NAFLD的糖代谢,还可以减少肝脏脂肪含量。 |
| 关键词: 2型糖尿病 非酒精性脂肪肝 二甲双胍 内脏脂肪 |
| DOI：10.3969/j.issn1008 -0392.2012.05.013 |
| 投稿时间：2011-10-23 |
| 基金项目: |
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| Liver fat contents in type 2 diabetic patients with nonalcoholic fatty liver disease under metformin treatment |
| ZHAO Bang-feng,WU Guo-ting |
| (Dept.of Endocrinology,Tenth People’s Hospital,Tongji University,Shanghai 200072,China) |
| Abstract: |
| Objective To investigate the change of liver fat contents in type 2 diabetic patients with non-alcoholic fatty liver disease (NAFLD) under metformin treatment. Methods Fifty patients with type 2 diabetes mellitus (T2DM) and NAFLD were assigned to receive metformin treatment (groupA， n =25) or non -metformin treatment (group B， n =25) . The intrahepatic fat contents were examined by MRS; the mass of fat peak/the mass of fat peak + the mass of water peak > 5. 5% was diagnosed as NAFLD. Results Twenty four cases in each group were completed with treatment and followed up. There were no significant differences in liver fat accumulation between two groups (P >0. 05) ; however， after treatment the TC，BMI， FPG， HbA1c and TG levels in group A were significantly lower than those in group B. Conclusion Metformin can improve glycometabolism in T2DM patients with NAFLD. |
| Key words: type 2 diabetes mellitusi non-alcoholic fatty liver disease metformini visceral fat |
