| 引用本文： |
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高青梅,梁爱斌.特发性血小板减少性紫癜血小板生成素的测定及其临床意义[J].同济大学学报（医学版）,2012,33(4):46-48. [点击复制]
- GAO Qing-mei,LIANG Ai-bin.Serum thrombopoietin levels in patients with idiopathic thrombocytopenic purpura and its significance[J].同济大学学报（医学版）,2012,33(4):46-48. [点击复制]
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| 摘要: |
| 目的 研究特发性血小板减少性紫癜(idiopathic thrombocytopenic purpura,ITP)患者血清血小板生成素(thrombopoientin,TPO)水平改变与疗效的关系。方法 选取我院45例ITP患者(ITP组)和25例体检正常者(对照组),应用酶联免疫吸附法定量检测2组患者治疗前后TPO浓度,同时分别采用血细胞分析仪及骨髓涂片法检测治疗前后ITP患者外周血血小板和骨髓巨核细胞的数量,并根据治疗1个月后患者的疗效情况,将ITP患者分为治疗有效组和治疗无效组。结果 ITP组与对照组相比,血小板计数及巨核细胞计数差异显著,具有统计学意义(P＜0.05),而TPO浓间差异无显著性,不具有统计学意义(P＞0.05);治疗前,ITP组中治疗无效组的TPO浓度明显高于治疗有效组和对照组(P＞0.05),而巨核细胞计数明显低于治疗有效组和对照组。结论 血清TPO水平在ITP患者预后判断中具有重要意义。 |
| 关键词: 特发性血小板减少性紫癜 血小板生成素 疗效 |
| DOI：10.3969/j.issn1008-0392.2012.04.010 |
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| 基金项目: |
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| Serum thrombopoietin levels in patients with idiopathic thrombocytopenic purpura and its significance |
| GAO Qing-mei,LIANG Ai-bin |
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| Abstract: |
| Objective To investigate serum thrombopoietin (TPO) levels in patients with idiopathic thrombocytopenic purpura (ITP) and its significance. Methods The serum levels of thrombopoietin in ITP patients (n = 45) and healthy subjects (control group, n = 25) were tested by sandwich enzyme-linked immunosorbent assay. The peripheral platelet counts were measured by automatic hemocyte analyzer; and the bone marrow megakaryocytes were counted directly under microscope. Among 45 ITP patients, 37 were responders and 8 were non-responders to treatment. Results The counts of platelets in ITP patients significantly decreased (P＜0.05); and the counts of megakaryocytes increased (P＜0.05) . However, there was no significantly difference in serum TPO levels between ITP patients and control group. The TPO levels of responder ITP patients were significantly higher than those of non-responders and healthy controls (P＜0.05) ； The megakaryocyte counts of non-responder patients were significantly lower than that of patients in responders (P＜0.05). Conclusion The serum levels of thrombopoietin may be a useful indicator for effectiveness of treatment. |
| Key words: Purpura thrombocytopenic idiopathic Thrombopoietin Curative result |
