| 引用本文： |
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方霞,,易祥华.Wnt/β-catenin和EGFR信号通路在非小细胞肺癌发生发展中的作用[J].同济大学学报（医学版）,2012,33(1):105-109. [点击复制]
- FANG Xia,YI Xiang-hua.Wnt/β-catenin and EGFR signaling pathway in carcinogenesis and progression of non-small cell lung cancer[J].同济大学学报（医学版）,2012,33(1):105-109. [点击复制]
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| 摘要: |
| Wnt/β-catenin信号通路和EGFR信号通路在胚胎的形成与发育以及肿瘤发生发展中起着重要的作用,相关研究证实,在乳腺癌中Wnt1和Wnt5a可激活EGFR信号通路,肺癌中EGFR的过表达也可以促使核内β-catenin的蓄积,提示两者之间存在交叉作用。本文主要就EGFR和Wnt两条信号通路在非小细胞肺癌发生发展中的作用及其相互联系进行综述。 |
| 关键词: 肺肿瘤 非小细胞肺肿瘤 Wnt/β-catenin EGFR 交叉通路 |
| DOI：10.3969/j.issn1008-0392.2012.01.023 |
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| 基金项目:上海市科学技术委员会科研基金(034119868);上海市科学技术委员会医学重点科研基金(09411951600) |
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| Wnt/β-catenin and EGFR signaling pathway in carcinogenesis and progression of non-small cell lung cancer |
| FANG Xia,YI Xiang-hua |
| (Dept.of Pathology,Tongji Hospital,Tongji University,Shanghai 200065,China) |
| Abstract: |
| Wnt/β-catenin and EGFR signaling pathway are crucial in embryogenesis,tumor formation and progression.Studies have shown that Wntl and Wnt5a can activate EGFR signal pathway in mammary tumor;overexpression of EGFR in lung cancer can promote the accumulation ofβ-catenin in nucleus.It is indicated that cross-communication may exist between two pathways.This article reviews recent research advances in the function and cross-talking of these two pathways in non-small cell lung cancer. |
| Key words: pulmonary carcinoma non-small cell lung cancer Wnt/β-catenin EGFR cross-talking |
