MA Lei,QIAN Chun-mei,SUN Ke-li,et al.Mifepristone combined with misoprostol in treatment of 90 cases of missed abortion[J].同济大学学报（医学版）,2011,32(5):65-67. [点击复制]
Mifepristone combined with misoprostol in treatment of 90 cases of missed abortion
MA Lei,QIAN Chun-mei,SUN Ke-li,Lü Chao-xia,LIU Shi-ying,CHENG Jia-jing
(Dept, of Obstetrics and Gynecology, Tenth People’s Hospital, Tongji University, Shanghai 200072, China)
Abstract:
Objective To evaluate the efficacy of mifepristone combined with misoprostol in treatment of missed abortion.Methods Ninety missed abortion cases with 8~14 weeks of menelipsis were admitted from January 2010 to June 2010 in Tenth People’s Hospital,Tongji University.The patients were randomly divided into trial group(n=50) and control group(n=40).Patients in trial group were treated by sequential therapy:200 mg mifeprisone taken orally at the morning of the first day and then 600μg misoprostol administrated vaginally after 24 h.Misoprostol would be used again at the interval of 3 h until embryo discharged(at most 4 times).Patients in control group were given oral administration of diethylstibestrol,3 times per day for 3 days;intravenous drip of oxytocin was given on the 4 th day during uterine curettage.The efficacy was evaluated by B type ultrasonic examination 24 h after embryo discharged.Results In trial group,41 cases(82.0%) were identified as complete abortion,7 cases(14.0%) as incomplete abortion,and 2 cases(4.0%) needed further operations with a successful rate of 96%.In control group,13 cases(32.5%) were identified as complete abortion,8 cases(20.0%) as incomplete abortion and 19 cases(47.5%) needed further operations with an overall successful rate of 52.5%.The rate of complete abortion was significantly higher in trial group than that in control group(P＜0.05).Conclusion The application of mifepristone combined with misoprostol in treatment of missed abortion has advantages of higher successful rate,lower operation rate,fewer blood loss and complications.
