| 摘要: |
| 目的 观察牙齿移动过程中咖啡因对牙槽骨改建的影响。方法 建立大鼠aY-畸牙移动模型，分别按照每日10mg/100g、2．5mg/100g给予咖啡因，在加力前及加力后第1天，第3天，第7天，第14天，第21天和第28天处死大鼠，通过H—E和TRAP染色观察牙周组织变化情况，行破骨细胞计数。结果 每日10mg/100g组压力侧破骨细胞数量多于对照组和每日2．5mg/100g组，牙槽骨吸收明显；而张力侧成骨作用不活跃，新生骨不如对照组和每日2．5mg/100g组明显。结论 牙齿移动过程中适当饮用咖啡因对牙槽骨的代谢没有明显影响，而大量饮用咖啡因则对骨的代谢具有潜在的影响，可能影响牙槽骨的改建。 |
| 关键词: 咖啡因 牙槽骨 正畸 牙齿移动 大鼠 |
| DOI：10.3969/j.issn1008-0392.2011.03.006 |
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| 基金项目: |
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| Effect of caffeine on alveolar bone remodeling during orthodontic tooth movement in rats |
| SUN Peng,He Yong-chun |
| (Dept.of Orthodontics,Stomatology Hospital,Tongji University,Shanghai 200072,China) |
| Abstract: |
| Objective To investigate the effect of caffeine on alveolar bone remodeling during orthodontic tooth movement in rats.Methods Fifty-four male Sprague-Dawley rats were randomly divided into three groups;group A(n= 18) in which animals did not received caffeine ingestion;high and low dose caffeine groups(group B and C,n= 18 in each group) in which animals ingesting 10 mg or 2.5 mg/100 g body weight of caffeine via drinking water everyday.The upper right first molars were moved orthodontically by using a coil spring.The rats were sacrificed in 1,3,7,14,21 and 28 d after given caffeine in drinking water.Tissue sections were observed underlight microscope after haematoxylin-eosin(H-E) and tartrate-resistant acid phosphatase(TRAP) histochemistry.Results The result shown a significant increase number of osteoclast cells in the compression side and decrease osteoblast cells in the tention side in high-dose caffeine group compared with low dose caffeine and non-caffeine groups.Conclusion The present study indicated that daily intake of high doses caffeine may have an effect on the alveolar bone remodeling during orthodontic tooth movement. |
| Key words: caffeine alveolar bone orthodontic tooth movement rats |
