| 引用本文： |
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高富存,钟明安,刘斌,等.EGFR和COX-2在PBM患者胆囊黏膜上皮中的表达及意义[J].同济大学学报（医学版）,2011,32(2):31-34. [点击复制]
- GAO Fu-cun,ZHONG Ming-an,LIU Bin,et al.The expression and the significance of epidermal growth factor receptor and cyclooxygenase-2 in gallbladder epithelial cells with pancreaticobiliary maljunction[J].同济大学学报（医学版）,2011,32(2):31-34. [点击复制]
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| 摘要: |
| 目的 探讨表皮生长因子受体（epidermal growth factor receptor,EGFR）和环氧合酶-2（cyclooxygenase-2,COX-2）在胰胆管汇合异常（pancreaticobiliary maljunction,PBM）患者胆囊黏膜上皮中表达及临床意义。方法应用免疫组化S-P法检测PBM和非PBM慢性胆囊炎患者胆囊黏膜上皮中COX-2和EGFR蛋白的表达。结果 22例PBM患者胆囊黏膜上皮中,COX-2表达为（-）2例,（＋）3例、（＋＋）6、（＋＋＋）11例,对照组（-）4例、（＋）9例、（＋＋）8例、（＋＋＋）1例;PBM患者胆囊黏膜上皮中EGFR表达为（-）2例,（＋）2例、（＋＋）9例、（＋＋＋）9例,对照组为（-）6例、（＋）4例、（＋＋）10例、（＋＋＋）2例。两者均较对照组表达增高,差异有统计学意义（P＜0.05）,且PBM患者胆囊黏膜上皮中COX-2和EGFR表达有相关性（r=0.584,P＜0.05）。结论 COX-2和EGFR在胰胆管汇合异常患者胆囊黏膜上皮中表达升高,且有相关性,可能对PMB患者胆囊上皮过度增生-不典型增生-癌变过程有促进作用。 |
| 关键词: 胰胆管汇合异常 表皮生长因子受体 环氧合酶-2 癌变机制 |
| DOI：10.3969/j.issnl008-0392.2011.02.007 |
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| 基金项目:上海市浦东新区社会发展局项目（PW2007-A6) |
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| The expression and the significance of epidermal growth factor receptor and cyclooxygenase-2 in gallbladder epithelial cells with pancreaticobiliary maljunction |
| GAO Fu-cun,ZHONG Ming-an,LIU Bin,ZHOU Zhu-qing,ZHAO Zhong-xin |
| (Dept.General Surgery,East Hospital,Tongji University,Shanghai 200120,China) |
| Abstract: |
| Objective To investigate the expression and the significance of epidermal growth factor receptor and cyclooxygenase-2 in gallbladder epithelial cells with pancreaticobiliary maljunction (PBM).Methods The expressions of epidermal growth factor receptor and cyclooxygenase-2 in gallbladder epithelial cells with or without PBM were detected by using S-P immunohistochemical staining.Results The expressions of COX-2 in gallbladder epithelial cells of 22 patients with PBM were 2 cases of score(-),3 score(+),6 score(+ +),and 11 score(+ + +),respectively.They were significantly higher than those in the control group with the same number of patients.They were: 4 cases of score(-),9 score(+),8 score(+ +),and 1 score(+ + +).The expressions of EGFR in gallbladder epithelial cells of 22 patients with PBM were:2 cases of score(-),2 score(+),9 score(+ +),and 9 score(+ + +),respectively.They were significantly higher than those in me control group with the same number of patients.They were:6 cases of score(-),4 score(+),10 score (+ +),and 2 score(+ + +).There was also significant correlation between EGFR and COX-2 in gallbladder epithelial cells with PBM(r=0.584,P＜0.05).Conclusions The expressions of EGFR and COX-2 were significantly higher and positively correlated in gallbladder epitheUal cells with PBM,and this may play an important role in the hyperplasia-dysplasia-adenocarcinoma sequence of gallbladder epithelial cells with PBM. |
| Key words: pancreaticobiliary maljuntion epidermal growth factor receptor cyclooxygenase-2 carcinogenesis |
