HE Jian-yu,LI Shi-ying,XU Wei-ming,et al.Clinical effects of Docetaxel combined Cisplatin and Oxalipliatin on chemotherapy patients with advanced non-small cell lung cancer[J].同济大学学报(医学版),2010,31(6):83-88. [点击复制]
Clinical effects of Docetaxel combined Cisplatin and Oxalipliatin on chemotherapy patients with advanced non-small cell lung cancer
HE Jian-yu,LI Shi-ying,XU Wei-ming,HE Zhong-hui,GU Yang-hui,ZHU Ying
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Abstract:
Objective To study the short term efficacy and side effects of Docetaxel combined with Oxaliplatin and Docetaxel combined with Cisplatin on patients with advanced non-small cell lung cancer (NSCLC).Methods Patients with NSCLC were randomly divided into two groups:Docetaxel combined with Oxaliplatin as treatment group and Docetaxel combined with Cisplatin as control group. Docetaxel 75 mg/m^2 and Oxaliplatin 135 mg/m^2 were injected intravenously and the injection of Oxaliplatin was repeated every 21 d.Cisplatin 75 mg/m^2 were injected in three days(1,2 and 3 d) and repeated every 21 d.Curative effects and side effects were compared after 4 weeks.Results In treatment group,there were 5 patients having complete response(CR),16 patients partial response (PR),18 patients stable disease(SD),6 patients progressive disease(PD) and the overall response rates was 51.1%.In control group,there were 3 patients having CR,14 patients PR,18 patients SD,4 patients PD,the overall response rate was 46.1%.One-year survival rates were 31.1%in treatment group and 30.1%in control group(P0.05).The mean overall survival time(mOST) were(8.7±4.7) month,95%IC were 7.3 -10.3 month in treatment group and(8.5±4.9)month,95%IC were 6.9-10.1 month in control group,there were no significantly difference(P =0.71).The neural toxicity in treatment group was lower than that in control group(P0.05).The liver and renal function lesions, nausea,vomiting and the side effects of blood in treatment group were significantly lower than those in control group(P0.05).Conclusion The effectiveness of Docetaxel plus Oxaliplatin and Docetaxel plus Cisplatin are similar,but the Docetaxel plus Oxaliplatin have lower emesis,nausea,liver and renal toxicity,which can take the place of Docetaxel plus Cisplatin as the first line of chemotherapy.