| 引用本文： |
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孙斌,徐光辉.肝硬化患者糖代谢、血清胰岛素及胰高血糖素的变化[J].同济大学学报（医学版）,2010,31(5):79-81. [点击复制]
- SUN-bin,XU Guang-hui.The changes of glycometabolism,serum insulin and glucagons levels in the patients with hepatocirrhosis[J].同济大学学报（医学版）,2010,31(5):79-81. [点击复制]
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| 摘要: |
| 目的观察肝硬化患者糖代谢变化,探讨其可能机制与肝储备功能的关系。方法 46例肝硬化患者进行口服糖耐量试验、胰岛素释放试验及胰高血糖素的测定,并与同期住院36例非肝病患者进行比较。结果肝硬化组和对照组空腹血糖均正常,分别为（5.0±2.8）mmol/L和（4.9±1.9）mmol/L（P〉0.05）;餐后2h,肝硬化组血糖为（10.4±5.2）mmol/L,对照组血糖为（7.8±2.2）mmol/L,肝硬化组血糖升高更为明显（P〈0.05）。两组空腹血清胰岛素均正常,分别为（17.2±6.3）Um/L和（10.2±7.0）Um/L（P〉0.05）;餐后2h,肝硬化组胰岛素为（55.9±11.2）Um/L,对照组胰岛素为（35.7±12.2）Um/L,肝硬化组胰岛素升高更为明显（P〈0.05）。肝硬化患者胰高血糖素较对照组明显增高,分别为（256.14±76.1）ng/L和（67.9±26.6）ng/L（P〈0.05）。结论肝硬化患者糖代谢异常,且随肝功损害加重,胰高血糖素增高,提示胰岛素抵抗参与其发生过程。 |
| 关键词: 肝硬化 糖耐量 胰岛素释放试验 胰高血糖素 |
| DOI：10. 3969/j. issn1008 — 0392. 2010. 05. 019 |
| 投稿时间：2010-04-12 |
| 基金项目: |
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| The changes of glycometabolism,serum insulin and glucagons levels in the patients with hepatocirrhosis |
| SUN-bin1,XU Guang-hui2 |
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| Abstract: |
| Objective To study the changes of glycometabolism,serum insulin and glucagons levels in hepatocirrhotic patients and to discuss its possible pathogenesis and relationship with the hepatic reserve capacity in hepatocirrhosis.Methods Forty-six hepatocirrhosis and 38 non-liver diseases in-patients as control were selected in this study.The oral glucose tolerance test（OGTT）,serum insulin and glucagon levels were determined.Results The serum fasting glucose levels were normal in hepatocirrhosis（5.0±2.8 mmol/L） and control group（4.9±1.9 mmol/L）.The serum levels of postprandial glucose were increased in both groups.However,the elevated level was significantly higher in hepatocirrhosis group（10.4±5.2 mmol/L） than that in control group（7.8±2.2 mmol/L）.The serum levels of fasting insulin were normal in both groups（17.2±6.3 Um/L and 10.2±7.0 Um/L,respectively）.The serum postprandial insulin increased in the two groups,but increased serum level of postprandial insulin was significantly higher,in hepatocirrhosis group（55.9±11.2 Um/L） than that in control group（35.7±12.2 Um/L）.The serum level of glucagon in patients with hepatocirrhosis（5.1±2.7mmol/L） was significantly higher than that in non-liver diseases group（4.9±1.8 mmol/L）.Conclusion The patients with hepatocirrhosis had abnormal glycometabolism,it increasing with live function deterioration according to Child＇s grade.Insulin resistance may involve abnormal glycometa-bolism in patient with hepatocirrhosis since abnormally high concentration of serum glucagon was found in these patients. |
| Key words: hepatocirrhosis oral glucose tolerance test insulin releases test glucagon |
