| 引用本文： |
-
彭爱梅,王昌惠,李(譞),等.COPD合并OSAHS的临床研究[J].同济大学学报（医学版）,2010,31(3):92-95. [点击复制]
- PENG Ai-mei,WANG Chang-hui,LI Xuan,et al.Clinical study of chronic obstructive pulmonary disease complicated with sleep apnea hypopnea syndrome[J].同济大学学报（医学版）,2010,31(3):92-95. [点击复制]
|
|
| 摘要: |
| 目的探讨慢性阻塞性肺病（chronic obstructive pulmonary disease，COPD）合并阻塞性睡眠呼吸暂停低通气综合征（obstructive sleep apnea hypopnea syndrome，OSAHS）亦称重叠综合征（overlap syndrome，OS）和COPD患者肺功能和睡眠结构的变化。方法对37例COPD、32例重叠综合征患者分别进行多导睡眠图（polysomnography，PSG）监测及肺功能测定，并对各组数据作统计学舱验。结果重叠综合征组的第一秒用力呼气容积占预计值百分比（forced expiratory volume in onesecond，FEV1％），第一秒用力呼气容积占用力肺活量百分比（FEV1／FVC），最大通气量（MVV）均显著低于COPD组（P〈0．01，P〈0．05），而肺活量（vitalcapacity，VC），弥散功能（DLco）两纽间元显著差异；同时重叠综合征组的呼吸暂停低通气指数（apnea hypopneaindex，AHI）、最长呼吸暂停时间（the longest apnea time，LAT）和浅睡眠所占百分率（S1＋2）显著高于COPD组，而最低脉氧饱和度（LSaO2）、平均脉氧饱和度（MSaO2）、深睡眠所占百分率（S3＋4）显著低于COPD组（P〈0．01和P〈0．05）。结论重叠综合征患者夜间缺氧加重，睡眠结构改变明显，肺功能受损严重：对夜间缺氧明显的COPD患者及时检测多导睡眠图．便于及早诊治重叠综合征。 |
| 关键词: 慢性阻塞性肺病 重叠综合征 多导睡眠图 肺功能 睡眠结构 |
| DOI：10.3969/j.issnl008-0392.2010.03.023 |
| 投稿时间：2009-12-20 |
| 基金项目: |
|
| Clinical study of chronic obstructive pulmonary disease complicated with sleep apnea hypopnea syndrome |
| PENG Ai-mei,WANG Chang-hui,LI Xuan,FU Pei-fang,HUANG Mei-zheng,ZHANG Guo-liang |
| () |
| Abstract: |
| Objective To investigate the characteristics of lung tunction and changes of sleeping in patients with chronic obstructive pulmonary disease （COPD） complicated obstructive sleep apnea hypopnea syndrome （OSAHS, also called overlap syndrome, OS） and COPD. Methods Thirty two patients with OS and tbirty-seven patients with COPD were selected for collecting polysomnography （PSG） and lung functions data. The analysis of the data from each group was assessed by t test. Results Forced expiratory volume in one second（FEV1% ）, the percentage of FEV1% than forced vital capacit（FEV1/FVC）, maximal voluntary ventilation （MVV） in OS group were significantly lower than that of in COPD group （P〈0.01, P〈0.05）.However there were no significant differences in vital capacity（VC） and diffusion function（D Lco） between two groups. Moreover with in OS group, apnea hypopnea index（AHI）, the longest apnea time （LAT）, and the percentage of light sleep （S1 ＋2） were significantly increased, but the lowest oxygen saturation （LSaO2）, mean oxygen saturation （MSaO2）, and the percentage of deep sleep （S3 ＋4） were significantly lower when compared with COPD groups （P〈0.01 ,P〈0.05）. Conclusion Patients with OS have severe nighttime hypoxemia concomitant significant changes in sleeping characteristics and obstructive ventilator function. It is beneficial to detect PSG for patients with deficiency of oxygen during night sleep in order to find early stage of OSAHS. |
| Key words: chronic obstructive pulmonary disease overlap syndrome polysomnography lung function sleeping characteristics |
