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李冰馨,张亦涵,徐浣白.脂蛋白a的促炎、促血栓形成机制及临床价值的研究进展[J].同济大学学报（医学版）,2023,44(5):765-772. [点击复制]
LI Bingxin,ZHANG Yihan,XU Huanbai.Research Progress on pro-inflammatory and thrombotic mechanisms of lipoprotein(a) and its clinical implication[J].同济大学学报（医学版）,2023,44(5):765-772. [点击复制]

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脂蛋白a的促炎、促血栓形成机制及临床价值的研究进展
李冰馨,张亦涵,徐浣白
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(上海交通大学医学院附属第一人民医院内分泌科，上海 200080)

摘要:

脂蛋白a[lipoprotein(a), Lp(a)]是一种修饰的脂蛋白，主要由低密度脂蛋白样颗粒及载脂蛋白a[apolipoprotein(a), Apo(a)]所构成。已证明Lp(a)升高具有促动脉硬化作用；此外，其潜在的促炎、促血栓形成机制日益引起学界的关注。Apo(a)组分与纤溶酶原具有显著的同源性；并可以通过单核细胞活化、内皮功能障碍以及促进平滑肌细胞增殖参与炎症。多种降低Lp(a)的新型降脂药陆续被研发出来。本文主要从Lp(a)的结构出发，对Lp(a)的促炎、促血栓形成机制进行综述，并探讨其在临床应用中的价值。

关键词: 脂蛋白a 炎症血栓形成临床应用

DOI：10.12289/j.issn.1008-0392.23145

投稿时间：2023-05-02

基金项目:国家自然科学基金青年科学基金(81202113)；上海市自然科学基金(19ZR1440800)

Research Progress on pro-inflammatory and thrombotic mechanisms of lipoprotein(a) and its clinical implication

LI Bingxin,ZHANG Yihan,XU Huanbai

(Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China)

Abstract:

Lipoprotein(a)[Lp(a)] is a modified lipoprotein mainly composed of low-density lipoprotein(LDL) like particles and apolipoprotein(a)[Apo(a)]. In addition to promoting atherosclerosis, the potential mechanisms of promoting inflammation and thrombosis have attracted increasing attention. Apo(a) has significant homology with plasminogen, and participates in inflammation process through monocytes activation, endothelial dysfunction, and promotion of smooth muscle cell proliferation. New lipid-lowering drugs to reduce Lp(a) have been developed. This article reviews the pro-inflammatory and thrombotic mechanisms of Lp(a) based on its structure, and discusses its value of clinical applications.

Key words: lipoprotein(a) inflammation thrombosis clinical application