HONG Fangjing,HAN Ting,ZHUO Jialu,et al.Application of phase angle in nutritional evaluation and prognosis prediction of colorectal cancer patients undergoing surgery[J].同济大学学报（医学版）,2022,43(3):402-407. [点击复制]
Application of phase angle in nutritional evaluation and prognosis prediction of colorectal cancer patients undergoing surgery
HONG Fangjing,HAN Ting,ZHUO Jialu,LI Wei,GUO Panpan
(Anhui University of Science and Technology School of Medicine, Huainan 232001, Anhui Province, China;Department of Clinical Nutrition, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China)
Abstract:
ObjectiveTo explore the application of phase angle(PA) of bioelectrical impedance analysis(BIA) in nutritional evaluation and prognosis prediction of patients with colorectal cancer undergoing surgery. MethodsA total of 241 patients with colorectal cancer(CRC) undergoing surgery were included in the department of gastrointestinal surgery of Shanghai Tenth People’s Hospital, Tongji University. At admission, nutrition screening and assessment were performed using Nutrition Risk Screening 2002(NRS 2002), Patient-Generated Subjective Global Assessment(PG-SGA), Global Leadership Initiative on Malnutrition(GLIM). Body composition of patients was measured by BIA, while the relevant nutritional indexes and prognostic indexes were collected to evaluate the application of PA in nutritional evaluation and prognosis prediction. ResultsBody mass index(BMI), skeletal muscle mass index(SMI), serum prealbumin(PALB), total protein(TP), albumin(ALB), hemoglobin(HGB) and prognostic nutritional index(PNI) in the low PA group were lower than those in the normal PA group(P<0.05). Age, fibrinogen(FBG), neutrophil to lymphocyte ratio(NLR), platelet to lymphoccyte ratio(PLR) in the low PA group were increased(P<0.05). PA decreased significantly in patients with nutritional risk and malnutrition(P< 0.05). PA was consistent with NRS 2002 and GLIM(P<0.05). The PA values were negatively correlated with age, FBG, NLR, PLR, NRS 2002, PG-SGA, modified Glasgow prognostic score(mGPS) and GLIM(P<0.05), and were positively correlated with BMI, SMI, PALB, TP, ALB, HGB and PNI(P<0.05). Multiple linear regression analysis showed that age, SMI, PALB, HGB, PNI, mGPS and GLIM had significant effects on PA in patients with colorectal cancer undergoing surgery(P<0.05). ConclusionThe phase angle of bioelectrical impedance analysis is closely related to the nutritional status and prognosis of CRC patients, which may assist to identify the malnutrition and predict the prognosis of CRC patients undergoing surgery.
