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  • 陈健行,厚皎皎,王嘉仪,等.大学生精神病超高危群体的冲动与抑制特征及相关因素研究[J].同济大学学报(医学版),2022,43(1):77-84.    [点击复制]
  • CHEN Jianxing,HOU Jiaojiao,WANG Jiayi,et al.Characteristics of impulsivity and inhibition and related factors in college students at ultra-high risk for psychosis[J].同济大学学报(医学版),2022,43(1):77-84.   [点击复制]
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大学生精神病超高危群体的冲动与抑制特征及相关因素研究
陈健行,厚皎皎,王嘉仪,巴彦,赵旭东,史靖宇
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(同济大学医学院,上海 200092; 上海市浦东新区精神卫生中心暨同济大学附属精神卫生中心临床心理科,上海 200120)
摘要:
目的 探索精神病超高危群体的冲动与抑制特征及其社会心理影响因素。方法 在某大学9 039名新生中筛查出17名精神病超高危个体,并招募了23名健康大学生设置对照,使用Go-Nogo反应抑制与风险决策的反向学习范式进行行为学测量,并使用问卷评估社会心理因素。结果 提示高危组与正常对照组在行为学任务中的表现差异无统计学意义(P>0.05),但焦虑抑郁水平、神经质人格、冲动性、人际关系事件的差异有统计学意义(P<0.05),相关分析提示这些心理特征与反应抑制功能及冲动行为决策存在相关。结论 精神病超高危大学生的冲动和抑制功能行为表现差,但受损尚不显著。神经质人格、冲动性、焦虑抑郁水平差异有统计学意义(P<0.05),后两者与其冲动和抑制功能相关,提示这些社会心理因素与精神病前驱期认知功能损害存在潜在关联,是早期干预的重要靶点。
关键词:  社会心理功能  反应抑制  精神病超高风险  冲动性  心理干预
DOI:10.12289/j.issn.1008-0392.21173
投稿时间:2021-04-30
基金项目:上海市卫生健康委员会科研课题计划资助(202040030);上海市浦东新区医学临床高原学科建设项目资助(PWYgy2018-10)
Characteristics of impulsivity and inhibition and related factors in college students at ultra-high risk for psychosis
CHEN Jianxing,HOU Jiaojiao,WANG Jiayi,BA Yan,ZHAO Xudong,SHI Jingyu
(School of Medicine, Tongji University, Shanghai 200092, China;School of Medicine, Tongji University, Shanghai 200092, China; Department of Clinical Psychology, Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University, Shanghai 200120, China)
Abstract:
Objective To explore the characteristics of impulsivity and inhibition and related social psychological factors of college students with ultra-high risk for psychosis. Methods Seventeen individuals were identified as ultra-high risk for psychosis(UHR-p) from a screening among 9 039 freshmen in a university(UHR group), and 23 healthy college students were recruited as control group. The behavioral measurement was conducted using the risk decision-making reverse learning paradigm and the Go/Nogo response inhibition paradigm; and the social psychological factors were evaluated by questionnaire. Results There were significant differences in levels of anxiety and depression, neuroticism personality, impulsivity and interpersonal relationship events, while no significant difference in behavior tasks between UHR group and control group. Correlation analysis suggested that these psychological characteristics were related to the presence of response inhibition function and impulse behavior of decision-making. Conclusion The impulsive and inhibitory function of college students with UHR-p is lower, but the damage is not significant. There are significant differences in neurotic personality, impulsivity, anxiety-depression levels between UHR group and control group, the last two factors are correlated with their impulsive and inhibitory function. The study suggests that these psychosocial factors are potentially related to the impairment of cognitive function in the prodromal stage of psychosis, which is an important target of early intervention.
Key words:  psychosocial functioning  response inhibition  ultra-high risk for psychosis  impulsivity  psychological intervene

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