| 摘要: |
| 肠缺血再灌注（ischemia-reperfusion, I/R）损伤是临床上常见的病理生理过程，是指组织或器官缺血后重获血供反而加重损伤的现象。其发病率逐年上升，但目前仍缺乏有效的治疗手段和药物。近年来间充质干细胞(mesenchymal stem cells, MSCs)移植治疗肠I/R损伤成为研究热点。本文对MSCs移植治疗肠I/R损伤的研究进展进行综述。 |
| 关键词: 间充质干细胞 肠缺血再灌注损伤 外泌体 免疫调节 炎症 |
| DOI：10.12289/j.issn.1008-0932.21164 |
| 投稿时间：2020-04-27 |
| 基金项目:上海市浦东临床高峰学科(PWYgf2018-05);上海市浦东新区卫生系统重要薄弱学科建设资助(PWZbr2017-18) |
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| Progress on mesenchymal stem cells in treatment of intestinal ischemia-reperfusion injury |
| XU Yun-xin,WANG Qing-xiu |
| (Shanghai East Hospital Clinical Medical College, Nanjing Medical University, Nanjing 211166, China;Shanghai East Hospital Clinical Medical College, Nanjing Medical University, Nanjing 211166, China; Dept. of Anesthesiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China) |
| Abstract: |
| Ischemia-reperfusion（I/R) injury is a pathophysiological process in which the degree of tissue and organ damage is augmented after regaining blood supply on the basis of ischemic injury. Intestinal Ischemia/Reperfusion injury is common clinically; however, its treatment methods and relevant efficacy are limited. In recent years, mesenchymal stem cells（MSCs) transplantation has become a research hotspot in the treatment of intestinal I/R injury. This article reviews the research progress of MSCs therapy for intestinal I/R injury. |
| Key words: mesenchymal stem cells intestinal ischemia-reperfusion exosomes immune regulation inflammation |
