| 引用本文： |
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陈志勇,陈宇涵,陈媛媛,等.健康成人脂蛋白相关磷脂酶A2和髓过氧化物酶质量浓度参考区间的研究[J].同济大学学报（医学版）,2021,42(6):796-801. [点击复制]
- CHEN Zhi-yong,CHEN Yu-han,CHEN Yuan-yuan,et al.Study on reference interval of lipoprotein-associated phospholipase A2 and myeloperoxidase quality concentration in healthy adults[J].同济大学学报（医学版）,2021,42(6):796-801. [点击复制]
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| 摘要: |
| 目的 建立中国健康人群脂蛋白相关磷脂酶A2（lipoprotein-associated phospholipase A2, Lp-PLA2）和髓过氧化物酶（myeloperoxidase, MPO）的正常参考区间。方法 入选5 367名（男2 534名，女2 833名）健康成人，分别按年龄段分成六组： 20~29岁、30~39岁、40~49岁、50~59岁、60~69岁和≥70岁组，ElISA法测定血浆Lp-PLA2和MPO质量水平。参考区间根据美国临床和实验室标准协会（CLSI）C28-A2的标准建立。结果 男性LP-PLA2水平显著高于女性（P＜005）；女性组Lp-PLA2水平有明显的年龄依赖性升高趋势（P＜005），其中≥60岁组LP-PLA2水平显著高于＜60岁组（P＜005）。而在男性的各年龄亚组中这种趋势差异无统计学意义（P＞005）。男女两组及各年龄亚组间MPO水平差异均无统计学意义（P＞005）。中国健康成人Lp-PLA2及MPO水平参考区间分别为≤19070 ng/mL、≤9868 ng/mL。结论 在中国健康成人中建立两项指标的参考区间，将有助于指导临床筛查易感人群心脑血管意外，评估高危患者的危险性，进行早期干预，从而有效降低急性心肌梗死和中风的发生率。 |
| 关键词: 脂蛋白相关磷脂酶A2 髓过氧化物酶 参考区间 |
| DOI：10.12289/j.issn.1008-0932.21170 |
| 投稿时间：2021-04-29 |
| 基金项目:国家自然科学基金(81974041) |
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| Study on reference interval of lipoprotein-associated phospholipase A2 and myeloperoxidase quality concentration in healthy adults |
| CHEN Zhi-yong,CHEN Yu-han,CHEN Yuan-yuan,HUA Xue-sheng,JIANG Xue-ze,WANG Yue-peng |
| (Dep. of Cardiology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China) |
| Abstract: |
| Objective To establish the normal reference intervals of lipoprotein-associated phos-pholipase A2（Lp-PLA2) and myeloperoxidase（MPO) in Chinese healthy adults. Methods A total of 5 367 healthy adults（2 534 males and 2 833 females) were recruited in the study. There were six age groups： 20-29, 30-39, 40-49, 50-59, 60-69 and over 70 years. Plasma Lp-PLA2 and MPO quality levels were assayed by ELISA. The reference intervals were established according to the criteria of the American Clinical and Laboratory Standards Institute（CLSI) C28-A2. Results Lp-PLA2 levels in male were significantly higher than that in female（P<005). Lp-PLA2 levels had a significant trend in age-dependent increase in female（P<005), and the level in women over 60 years was significantly higher than that in women under 60 years（P<005). However, there was not significant difference in Lp-PLA2 levels among males of all age groups（P>005). There were no significant differences in MPO levels between males and females and among different age groups（P>005). The reference intervals of Lp-PLA2 and MPO levels in healthy Chinese adults were ≤19070 ng/mL and ≤9868 ng/mL respectively. Conclusion The reference intervals of plasma Lp-PLA2 and MPO quality levels for healthy Chinese adults have been established in the study, which can be used for screening of susceptible population, evaluating the high-risk patients to carry out early intervention of cardiovascular and cerebrovascular diseases. |
| Key words: lipoprotein-associated phospholipase A2 myeloperoxidase reference interval |
