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  • 任真,吕金辉,张丽波,等.肿瘤来源外泌体调控癌细胞转移机制的研究进展[J].同济大学学报(医学版),2021,42(5):705-710.    [点击复制]
  • REN Zhen,LU Jin-hui,ZHANG Li-bo,et al.Research progress of tumor-derived exosomes in regulating cancer metastasis and its mechanism[J].同济大学学报(医学版),2021,42(5):705-710.   [点击复制]
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肿瘤来源外泌体调控癌细胞转移机制的研究进展
任真,吕金辉,张丽波,程晓馨,俞作仁
0
(大连医科大学细胞生物学教研室,辽宁 大连116041; 同济大学医学院东方医院转化医学研究中心,上海200120)
摘要:
外泌体在细胞生理、病理过程中发挥重要调控作用,为细胞之间的信号传递搭建了桥梁,而且与癌细胞的远处转移调控密切相关。本文综述了外泌体特征、合成、分泌、成分、功能、生物发生以及肿瘤来源外泌体对肿瘤微环境、肿瘤细胞信号传递以及肿瘤血管生成等各个环节的调控功能及机制,并分析了外泌体在恶性肿瘤转移诊断和治疗方面的潜在价值和应用前景。
关键词:  外泌体  肿瘤细胞  转移  微环境
DOI:doi: 10.12289/j.issn.1008-0392.21150
投稿时间:2021-04-15
基金项目:上海市科委科技创新项目(20JC1410400);国家自然科学基金面上项目(81772810、81972476)
Research progress of tumor-derived exosomes in regulating cancer metastasis and its mechanism
REN Zhen,LU Jin-hui,ZHANG Li-bo,CHENG Xiao-xin,YU Zuo-ren
(Dept.of Cell Biology, Dalian Medical University, Dalian 116041, Liaoning Province, China; Research Center for Translational Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China)
Abstract:
Exosomes play an important regulatory role in cell physiology and pathology, such as involving in intercellular signal transmission and regulating distant metastasis of cancer cells. This article elucidates the characteristics, synthesis, secretion, composition, function and biogenesis of exosomes, and reviews the recent progress on the roles of tumor-derived exosomes in epithelial-mesenchymal transition(EMT) and cancer metastasis through regulating cancer microenvironment, signal transmission and tumor angiogenesis. In addition, the prospect of the potential application of exosomes in diagnosis and treatment of human cancer metastasis is also discussed.
Key words:  exosome  human cancer  metastasis  microenvironment

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