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  • 杜涛,张顺,崔锡茂,等.长链非编码RNA WT1-AS预测胃癌新辅助化疗疗效的临床价值[J].同济大学学报(医学版),2021,42(5):612-615.    [点击复制]
  • DU Tao,ZHANG Shun,CUI Xi-mao,et al.Clinical value of LncRNA WT1-AS in predicting the efficacy of neoadjuvant chemotherapy for gastric cancer[J].同济大学学报(医学版),2021,42(5):612-615.   [点击复制]
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长链非编码RNA WT1-AS预测胃癌新辅助化疗疗效的临床价值
杜涛,张顺,崔锡茂,蒋小华,韩俊毅
0
(同济大学附属东方医院胃肠外科,上海200120)
摘要:
目的探讨长链非编码RNA WT1-AS预测胃癌新辅助化疗疗效的临床价值。方法回顾性分析63例行新辅助化疗的进展期胃癌临床资料,并检测胃癌组织WT1-AS表达,采用单因素、多因素Logistic回归模型分析临床系数与新辅助化疗疗效的相关性,ROC曲线检测WT1-AS预测化疗疗效的效力;体外检测经不同浓度5-Fu处理的WT1-AS正常表达和过表达胃癌细胞的凋亡情况。结果新辅助治疗有效与否和肿瘤分化程度、TNM分期和WT1-AS表达显著相关(P<0.05),肿瘤分化程度、TNM分期和WT1-AS表达是进展期胃癌新辅助化疗疗效的独立预测因子;WT1-AS促进5-Fu致细胞凋亡(P<0.05)。结论WT1-AS可作为进展期胃癌新辅助疗效的潜在预测因子。
关键词:  WT1-AS  新辅助化疗  胃癌  可行性
DOI:10.12289/j.issn.1008-0392.21175
投稿时间:2021-05-06
基金项目:国家自然科学基金(81871953);上海市浦东新区科技发展基金(PKJ2016-Y60);江西省青年科学基金(S2017QNJJB1424)
Clinical value of LncRNA WT1-AS in predicting the efficacy of neoadjuvant chemotherapy for gastric cancer
DU Tao,ZHANG Shun,CUI Xi-mao,JIANG Xiao-hua,HAN Jun-yi
(Dept. of Gastrointestinal Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China)
Abstract:
ObjectiveTo study the clinical value of LncRNA WT1-AS in predicting the efficacy of neoadjuvant chemotherapy for gastric cancer. MethodsThe clinical data of 63 patients with advanced gastric cancer who underwent neoadjuvant chemotherapy were retrospectively analyzed. The expression of WT1-AS in gastric cancers was detected. The relationship between clinical characteristics and the efficacy of neoadjuvant chemotherapy was analyzed by univariate and multivariate Logistic regression models. The ability of WT1-AS in predicting chemotherapy efficacy was explored by ROC curve. Furthermore, cultured SGC7901 cells were transfected with LncRNA WT1-AS to study the effect of WT1-AS on resistance to 5-Fu chemotherapy. ResultsThe efficacy of neoadjuvant chemotherapy for gastric cancer was significantly correlated with tumor differentiation, TNM stage and WT1-As expression(P<0.05). The degree of tumor differentiation, TNM stage and WT1-As expression were independent predictors for efficacy of neoadjuvant chemotherapy in advanced gastric cancer. In vitro study showed that WT1-AS promoted apoptosis induced by 5-Fu. ConclusionLncRNA WT1-AS may be used as a potential predictor for efficacy of neoadjuvant chemotherapy in advanced gastric cancer.
Key words:  WT1-AS  neoadjuvant chemotherapy  gastric cancer  feasibility

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