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  • 余乐,王清秀.麻醉药抗抑郁作用的研究进展[J].同济大学学报(医学版),2021,42(4):574-580.    [点击复制]
  • YU Le,WANG Qing-xiu.Research progress on antidepressant effect and mechanism of anesthetics[J].同济大学学报(医学版),2021,42(4):574-580.   [点击复制]
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麻醉药抗抑郁作用的研究进展
余乐,王清秀
0
(南京医科大学上海东方临床医学院,南京210029; 同济大学附属东方医院麻醉科/疼痛科,上海200120)
摘要:
选择性5-羟色胺再摄取抑制剂(selective serotonin reuptake inhibitor, SSRI)是当前最常用的抗抑郁药。尽管该药较之前的抗抑郁药取得明显进步,但依旧存在起效慢、副作用多等问题。常用的麻醉药氯胺酮具有抗抑郁特性和起效快、副作用小等众多优点。丙泊酚、异氟烷等麻醉药也相继被发现具有抗抑郁的效果。本文对常见麻醉药品抗抑郁作用的研究进展进行综述。
关键词:  麻醉药  氯胺酮  艾司氯胺酮  丙泊酚  异氟烷  抑郁症
DOI:10.12289/j.issn.1008-0392.20523
投稿时间:2020-12-10
基金项目:上海市浦东临床高峰学科(PWYgf2018-05);上海市浦东新区卫生系统重要薄弱学科建设资助(PWZbr2017-18)
Research progress on antidepressant effect and mechanism of anesthetics
YU Le,WANG Qing-xiu
(Shanghai East Hospital Clinical Medical College, Nanjing Medical University, Nanjing 210029, China;Shanghai East Hospital Clinical Medical College, Nanjing Medical University, Nanjing 210029, China; Dept. of Anesthesiology and Pain Management, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China)
Abstract:
Selective serotonin reuptake inhibitors(SSRI) are the most commonly used antidepressants currently. Although it has made significant progress over the old antidepressants, problems such as the slow onset of action and multiple side effects still exist. Ketamine, a commonly used anesthetic, has been found to have antidepressant properties as well as rapid onset of action with little side effect. Other anesthetics such as propofol and isoflurane also have antidepressant effects. This article reviews the research progress of the antidepressant effects of common anesthetics.
Key words:  anesthetics  ketamine  esketamine  propofol  isoflurane  depression

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