| 引用本文： |
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熊梦婷,胥迎春,傅虹.基于SEER数据库的小细胞肺癌患者脑转移临床特征及预后分析[J].同济大学学报（医学版）,2021,42(2):236-242. [点击复制]
- XIONG Meng-ting,XU Ying-chun,FU Hong.Clinical characteristics and prognosis of brain metastasis in patients with small cell lung cancer based on SEER database[J].同济大学学报（医学版）,2021,42(2):236-242. [点击复制]
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| 摘要: |
| 目的基于SEER数据库分析小细胞肺癌(small cell lung cancer, SCLC)脑转移（brain metastases， BM）患者的临床特征及预后相关因素。方法使用美国监测、流行病学和结局数据库（SEER数据库），收集2010—2015年具有完整临床信息的SCLC患者的27 872例，根据2015年的随访结果将SCLC病例分为脑转移组和无脑转移组。通过单因素和COX多因素分析SCLC患者的性别、种族、年龄、肿瘤大小、好发部位、分化程度和诊断年份等临床特征与脑转移发生率的关联。根据Kaplan-Meier分析脑转移对SCLC患者肺癌特异性生存率（cancer-specific survival, CSS）和总生存率（overall survival, OS）的影响。此外，进一步分析手术、放射疗法和化学疗法对脑转移患者CSS和OS的影响。结果在72个月的随访期间，27 872例原发性SCLC中脑转移的发生率为17％。与20~39年龄组相比，≥80年龄组患者脑转移发生率低（HR=1.151,95%CI： 1.157~1.297，P=0.02）。脑转移患者的中位生存期（6.5个月）低于无脑转移患者（9.8个月）（P<0.001）。男性SCLC患者脑转移发生率高（HR=0.883，95%CI： 0.833~0.937，P<0.01）。相比未放疗组，放疗组SCLC患者脑转移发生率更低（HR=0.369，95%CI： 0.346~0.394，P<0.01）。结论SCLC患者脑转移的生存率低并且因年龄和性别而异。此外，放射疗法对脑转移患者的的生存率有益。 |
| 关键词: 小细胞肺癌 脑转移 SEER数据库 生存分析 |
| DOI：10.12289/j.issn.1008-0392.20423 |
| 投稿时间：2020-09-28 |
| 基金项目: |
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| Clinical characteristics and prognosis of brain metastasis in patients with small cell lung cancer based on SEER database |
| XIONG Meng-ting,XU Ying-chun,FU Hong |
| (Dept. of Tuberculosis, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China;School of Medicine, Tongji University, Shanghai 200092, China;Dept. of Emergency, Shanghai Pudong Hospital, Shanghai 201399, China) |
| Abstract: |
| ObjectiveTo analyze the clinical characteristics and prognosis of patients with brain metastases（BM）from small cell lung cancer（SCLC） based on SEER database. MethodsA total of 27 872 SCLC patients with complete clinical information were collected from United States Surveillance, Epidemiology, and Final Results Registry（SEER database) between 2010 and 2015. According to the follow-up results in 2015, SCLC cases were divided into BM group and non-BM group. Univariate and multivariate COX analyses were used to analyze the relationship between the clinical characteristics of SCLC patients and the incidence of BM. Kaplan-Meier curve was used to determine the cancer-specific survival（CSS) and overall survival（OS) of patients; the effect of BM on CSS and OS was analyzed; in addition, the effects of surgery, radiation therapy and chemotherapy on CSS and OS of BM patients were further analyzed. ResultsDuring the 72-month follow-up, the incidence of BM in 27 872 cases of primary SCLC was 17%. Compared with the 20-39 age group, the incidence of BM was lower in the ≥80 age group（HR=1.151, 95%CI： 1.157-1.297, P=0.02). The median survival time of BM patients was lower than that of patients without BM（6.5 months vs 9.8 months, P<0.001). The incidence of BM in male SCLC patients was higher（HR=0.883, 95%CI： 0.833-0.937, P<0.01). In addition, compared with the non-radiotherapy group, the incidence of BM in the radiotherapy group was lower（HR=0.369, 95%CI： 0.346-0.394, P<0.01). ConclusionThe survival rate of SCLC patients with BM is low and varies with age and gender. In addition, radiation therapy has a beneficial effect on the survival of BM patients. |
| Key words: small cell lung cancer brain metastasis SEER database survival analysis |
