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  • 高巍,陈寒蓓,潘宇峰,等.2型糖尿病患者尿蛋白水平与血尿酸的关系[J].同济大学学报(医学版),2021,42(1):97-102.    [点击复制]
  • GAO Wei,CHEN Han-bei,PAN Yu-feng,et al.Relationship between proteinuria level and serum uric acid in type 2 diabetic patients[J].同济大学学报(医学版),2021,42(1):97-102.   [点击复制]
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2型糖尿病患者尿蛋白水平与血尿酸的关系
高巍,陈寒蓓,潘宇峰,倪衡如,杜郁华
0
(上海交通大学医学院附属新华医院内分泌科,上海200092; 上海市宝山区淞南镇社区卫生服务中心,上海200441)
摘要:
目的分析影响2型糖尿病患者尿蛋白水平的相关临床危险因素,探讨尿蛋白水平与血清尿酸的关系。方法采用回顾性病例对照研究,收集2012年1月—2020年5月在上海交通大学附属新华医院内分泌科住院就诊的2型糖尿病患者共1998例,分析患者的实验室生化指标及临床相关检查,并采用多因素Logistic回归模型,探讨影响尿蛋白水平的潜在危险因素。结果基线资料中,大量尿蛋白组患者血清尿酸、肌酐显著高于微量尿蛋白组及无尿蛋白组,eGFR值显著低于微量尿蛋白组及无尿蛋白组(P<0.05)。Pearson相关分析结果显示,尿酸水平与ACR呈正相关。多因素Logistic回归分析结果显示,血清尿酸水平是T2DM患者尿白蛋白的独立危险因素(OR=1.001,95%CI 1.000~1.003,P=0.017)。结论在2型糖尿病患者中,血清高尿酸水平可能是影响尿蛋白的独立危险因素,对高尿酸进行早期干预有望延缓糖尿病肾脏疾病的发展。
关键词:  2型糖尿病  尿白蛋白肌酐比值  血尿酸  肾功能  慢性肾脏疾病
DOI:10.12289/j.issn.1008-0392.20258
投稿时间:2020-06-10
基金项目:上海市科学技术委员会科研计划项目(19ZR1433200)
Relationship between proteinuria level and serum uric acid in type 2 diabetic patients
GAO Wei,CHEN Han-bei,PAN Yu-feng,NI Heng-ru,DU Yu-hua
(Dept. of Endocrinology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China; Songnan Town Community Health Service Center, Baoshan District, Shanghai 200441, China)
Abstract:
ObjectiveTo investigate the relationship between proteinuria levels and serum uric acid in patients with type 2 diabetes (T2DM). MethodsClinical data of 1998 patients with type 2 diabetes who were admitted to the Department of Endocrinology, Xinhua Hospital, Shanghai Jiao Tong University from January 2012 to May 2020 were retrospectively analyzed. A multivariate logistic regression model was used to explore the potential risk factors affecting proteinuria. ResultsThe serum uric acid and creatinine levels were significantly higher, and eGFR was significantly lower in the albuminuria group than those in the microproteinuria group and the no proteinuria group (P<0.05). Pearson correlation analysis showed that uric acid level was positively correlated with urinary albumin creatinine ratio (ACR). Multivariate logistic regression analysis showed that serum uric acid level was an independent risk factor for albuminuria in patients with T2DM (OR=1.001, 95%CI 1.000 to 1.003, P=0.017). ConclusionIn patients with type 2 diabetes, serum high uric acid levels may be an independent risk factor affecting proteinuria, and early intervention with high uric acid may delay the development of diabetic nephropathy.
Key words:  type 2 diabetes  urine albumin creatinine ratio  serum uric acid  renal function  chronic kidney disease

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