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陈泽坤,石建明,王笑峰,等.中国社区老年人脑钠肽水平与衰弱指数的关系[J].同济大学学报（医学版）,2021,42(1):42-46. [点击复制]
CHEN Ze-kun,SHI Jian-ming,WANG Xiao-feng,et al.Association of brain natriuretic peptide with frailty index in Chinese community-dwelling elderly[J].同济大学学报（医学版）,2021,42(1):42-46. [点击复制]

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中国社区老年人脑钠肽水平与衰弱指数的关系
陈泽坤,石建明,王笑峰,蒋晓燕
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(同济大学医学院，上海200092;如皋市人民医院长寿研究所，江苏226500;复旦大学人类表型组研究院，上海200082)

摘要:

目的探讨社区老年人脑钠肽（brain natriuretic peptide, BNP）的异常升高与衰弱指数定义衰弱的关系。方法总计1449名年龄在70~89岁的中国社区居民参加了这项横断面研究。选用40个健康指标构建衰弱指数（frailty index, FI）。升高的BNP定义为BNP浓度>100pg/mL。结果衰弱指数的平均值为0.15±0.09。291名受试者（20.1%）的衰弱指数>0.21。与最低四分位数相比，最高的BNP四分位数具有更高的衰弱风险，多因素调整后的比值比为1.92（95%CI 1.19~3.09）。经协变量调整后，升高的BNP（>100pg/mL）与衰弱之间关联显著（OR 1.81, 95%CI 1.22~2.68）。在多变量调整后，BNP每增加1个标准差，衰弱的风险是1.27倍（95%CI 1.07~1.51）。经过对数转换后的BNP与衰弱指数正相关（r=0.16，P<0.001）。结论血浆BNP的升高与衰弱指数定义的衰弱风险增加相关。

关键词: 脑钠肽衰弱指数老年生物标志物

DOI：10.12289/j.issn.1008-0392.20390

投稿时间：2020-09-12

基金项目:国家重点研发计划（2018YFC2002000、2018YFC2000400）

Association of brain natriuretic peptide with frailty index in Chinese community-dwelling elderly

CHEN Ze-kun,SHI Jian-ming,WANG Xiao-feng,JIANG Xiao-yan

(Tongji University School of Medicine, Shanghai 200092, China;The People’s Hospital of Rugao, Rugao 226500, China;Fudan University Human Phenome Institute, Shanghai 200082, China)

Abstract:

ObjectiveTo explore the association of plasma brain natriuretic peptide (BNP) level with frailty index in community-dwelling Chinese elderly. MethodsA total of 1449 Chinese community residents aged 70-89 years participated in this cross-sectional study. The frailty index (FI) containing 40 health deficits was measured in the study. Elevated plasma BNP level was defined as BNP>100pg/mL. ResultsThe mean FI value was 0.15±0.09, and 291 (20.1%) participants were classified as frail (FI>0.21). Relative to the lowest quartile, the highest BNP quartile had a greater risk of prevalent frailty with adjusted odds ratios of 1.92 (95%CI 1.19-3.09). The elevated BNP level was significantly associated with a higher risk for frailty (OR 1.81, 95%CI 1.22-2.68) after adjustment for covariates. After a multivariable adjustment, the risk of frailty was 1.27 (95%CI 1.07-1.51) for a per-SD increase in BNP. Log BNP was positively correlated with FI (r=0.16， P<0.001). ConclusionElevated plasma BNP is associated with increased risks of frailty index in Chinese community-dwelling elderly.

Key words: brain natriuretic peptide frailty index elderly biomarker