| 摘要: |
| 阿尔茨海默病(Alzheimer’s disease, AD)是一种神经退行性疾病。主观认知下降(subjective cognitive decline, SCD)被认为是AD的临床前阶段，早期识别SCD可以将AD的防治关口前移。在SCD的众多诊断方法中，神经影像技术被认为是比较有前景的。本文就SCD结构磁共振、功能磁共振、扩散张量成像、PET/SPECT等影像学研究进展予以综述。 |
| 关键词: 主观认知下降 阿尔茨海默病 轻度认知障碍 |
| DOI：10.16118/j.1008-0392.2020.06.022 |
| 投稿时间：2020-03-09 |
| 基金项目:国家自然科学基金（81301200）；上海市科学技术委员会科研项目（19411951400）；上海市卫生和计划生育委员会科研项目（201740207）；上海市浦东新区卫生系统学科带头人培养计划（PWRd2016-07） |
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| Research progresses on imaging of subjective cognitive decline in Alzheimer’s disease |
| HAO Shang-ci,XI Qian |
| (Dept. of Radiology, East Hospital, Tongji University School of Medicine, Shanghai 200120, China) |
| Abstract: |
| Alzheimer’s disease (AD) is a common neurodegenerative disease. Subjective cognitive decline (SCD) is considered as the pre-clinical stage of AD, and early recognition of SCD can make the prevention and treatment of AD in advance. Among the diagnostic methods of SCD, neuroimaging technique is more promising. This article reviews the research progress of structural magnetic resonance imaging (MRI), functional MRI, diffusion tensor MRI and PET/SPECT for diagnosis of SCD in Alzheimer’s disease. |
| Key words: subjective cognitive decline Alzheimer’s disease mild cognitive impairment |
