| 引用本文： |
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赵婧,赵泓玮,宋亚华,等.胃内亮蓝嵴和白色不透明物质与胃黏膜肠上皮化生相关性分析[J].同济大学学报（医学版）,2020,41(5):638-643. [点击复制]
- ZHAO Jing,ZHAO Hong-wei,SONG Ya-hua,et al.Relationship between intragastric light blue crest, white opaque substance and gastric mucosa intestinal metaplasia[J].同济大学学报（医学版）,2020,41(5):638-643. [点击复制]
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| 摘要: |
| 目的评估胃内亮蓝嵴（light blue crest, LBC）、白色不透明物质（white opaque substance, WOS）等内镜下表现对胃黏膜肠上皮化生（gastric mucosa intestinal metaplasia, GIM）的诊断效能。方法纳入既往确诊为慢性萎缩性胃炎行胃镜早癌筛查患者，白光观察后行NBI-ME观察，并取活检病理确诊，比较胃内LBC及WOS的出现与GIM发生的相关性，分析LBC及WOS对GIM的诊断价值。结果共101例患者被纳入研究，GIM发病率为52.48%。LBC阳性组和LBC阴性组的GIM的发生率分别为71.74%和36.36%，两组间发生率差异有统计学意义（P＜0.0001）；WOS阳性组和WOS阴性组的GIM发生率分别为72.73%和50%，两组间GIM发生率差异无统计学意义（P＞0.05）；LBC、WOS均阳性或任一阳性与LBC、WOS均阴性GIM的发病率分别为70.37%和31.91%，两组间GIM发生率差异有统计学意义（P＜0.0001）。联合使用LBC及WOS的ROC曲线下面积为0.692（95%CI：0.587～0.797）。结论胃内LBC、WOS均阳性或任一阳性与GIM的组织学诊断有很强的相关性，可作为临床内镜下判断GIM的有效方法。胃黏膜萎缩类型及幽门螺杆菌（Hp）是否感染与GIM无明显相关性。 |
| 关键词: 肠上皮化生 亮蓝嵴 白色不透明物质 胃黏膜 |
| DOI：10.16118/j.1008-0392.2020.05.016 |
| 投稿时间：2019-12-01 |
| 基金项目:陕西省重点研发计划（2018ZDXM-SF-055） |
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| Relationship between intragastric light blue crest, white opaque substance and gastric mucosa intestinal metaplasia |
| ZHAO Jing,ZHAO Hong-wei,SONG Ya-hua,ZOU Bai-cang,DONG Lei,QIN Bin |
| (Dept. of Gastroenterology, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China) |
| Abstract: |
| ObjectiveTo evaluate the intragastric endoscopic manifestations of light blue crest(LBC) and white opaque substance(WOS) in the diagnosis of gastric mucosa intestinal metaplasia(GIM). MethodsIn 101 patients with chronic atrophic gastritis undergoing gastroscopic screening for early gastric cancer, the narrow band imaging and magnifying endoscopy(NBI-ME) were performed after conventional endoscopy, and biopsy was taken for pathological diagnosis. The correlation between intragastric LBC, WOS and GIM was analyzed, and the diagnostic value of LBC and WOS for GIM was assessed. ResultsAmong 101 patients, the overall prevalence of GIM was 52.48%; the prevalence of GIM in LBC positive group was 71.74% and that in LBC negative group was 36.36%(P＜0.0001); while the prevalence of GIM in WOS positive group was 72.73% and that in WOS negative group was 50.0%(P＞0.05). The prevalence of GIM in LBC+ and WOS+ or either of them+and WOS-groups were 70.37% and 31.91% respectively(P＜0.0001). The area under ROC curve of LBC combined with WOS was 0.692(95%CI：0.587～0.797). ConclusionsLBC+ and WOS+ and either of them+has a strong correlation with the histological diagnosis of GIM, which can be used as an effective method for endoscopic diagnosis of GIM. In addition, there is no significant correlation between GIM and atrophic types of gastric mucosa or the infection of Helicobacter pylori(Hp). |
| Key words: gastric mucosa intestinal metaplasia light blue crest white opaque substance gastric mucosa |
